The influence of a host defense protein, lactoferrin (LF), contained in exocrine secretions such as milk, on radiation disorder was investigated. A total of 25 C3H/He mice in each of two groups were maintained with 0.1% LF-added and LF-free diets, respectively, for one month. The mice were then treated with single whole-body X-ray irradiation at a sublethal dose (6.8 Gy), and the survival rate ...

Low-dose total-body irradiation, 150 rad given in 10 fractions over 5 weeks, is a useful treatment modality for favorable-prognosis lymphomas. Little is known, however, about the effects of this regimen on normal bone marrow. Six healthy beagle dogs and 5 dogs of various breeds with lymphoma were treated with total-body irradiation. Three of the 5 lymphomatous dogs achieved remissions of limite...

The objective was to study the effects of one time exposure to small clinically relevant dose of 60 cobaltgamma ( 60 Co-γ) radiation on histological changes in brain and consequent effects on conditioned taste aversion (CTA) in experimental rats. Rats were total body 60 Co-γ-irradiated in GammaCell; CTA to saccharin was assessed in terms of saccharin preference ratio (SPR) using a standardized ...

Introduction: Breast conserving radiotherapy is one of the most common procedures performed in any radiation oncology department. A tangential parallel-opposed pair is usually used for this purpose. This technique is performed using 2D or 3D treatment planning systems. The aim of this study was to compare 2D treatment planning with 3D treatment planning in tangential irradiation in breast conse...

PURPOSE To present the results of dose homogeneity analysis for breast cancer patients treated with image-based conformal interstitial brachytherapy, and to investigate the usefulness of the ICRU recommendations. MATERIAL AND METHODS Treatment plans of forty-nine patients who underwent partial breast irradiation with interstitial brachytherapy were analyzed. Quantitative parameters were used ...

ID: 13162 Title: 3D heterogeneous dose distributions for Total Body Irradiation Patients Purpose: One major objective of Total Body Irradiation (TBI) treatments is to deliver a uniform dose in the entire body of the patient. Looking at 3D dose distributions for constant speed (CteSpeed) and variable speed (VarSpeed) translating couch TBI treatments, dose uniformity and the effect of body hetero...

Introduction: The commonly used technique of radiation therapy for vulvar cancer consists of anteroposterior (AP) and posteroanterior (PA) fields. This is the first study that reports the dosimetric comparison between the AP-PA techniques and the new 3D advanced conformal technique (3D-ACT) based on the multiplicity of treatment fields in patients with squamous cell ca...

The ability of simvastatin to mitigate the increases in risk factors for and the occurrence of cardiac disease after 10 Gy total body irradiation (TBI) was determined. This radiation dose is relevant to conditioning for stem cell transplantation and threats from radiological terrorism. Male rats received single dose TBI of 10 Gy. Age-matched, sham-irradiated rats served as controls. Lipid profi...

Due to high frequency of side effects caused by high-dose total body irradiation (TBI) the nonmyeloablative regimen together with cytotoxic agents is currently used especially for elderly patients. However, immediate and long-term effects of low-dose irradiation used in allogeneic transplantation on stem cells is less well known. We have studied the effect of low-dose 3 Gy TBI on the number of ...

BACKGROUND Severe cataract and renal dysfunction are late effects following myeloablative total body irradiation (TBI) and hematopoietic stem cell transplantation in patients with hematological malignancies. The aim of the study was to determine radiation dose-response relationships for these late effects. MATERIALS AND METHODS A retrospective review of articles reporting incidences for catar...