CONTEXT To evaluate treatment success and hypothyroidism following main methods of radioiodine therapy of toxic nodular goiter (TNG); calculated versus fixed dose and high versus low dose of radioiodine. EVIDENCE ACQUISITIONS We searched MEDLINE and SCOPUS databases from inception till July 2013, for clinical trials that compared two different methods of radioiodine administration in TNG. The...

BACKGROUND A study had reported that a low TSH level is associated with elevated plasma fibrinogen (FIB) levels. Our purpose was to investigate the role of FIB in the differential diagnosis of thyrotoxicosis. METHODS The data of 104 patients with primary thyrotoxicosis at the First Hospital of China Medical University from July 2010 to March 2011 were analyzed and divided into three groups: 4...

The double antibody radioimmunoassay of serum thyroid-stimulating hormone (TSH) allows measurement of circulating levels of the hormone in most normal subjects. The serum TSH level in normal subjects is 1.6 +/- 0.8muU/ml. Patients with non-toxic goitre and acromegaly have normal TSH levels. Values are always raised in hypothyroid patients (with primary thyroid disease) and are significantly low...

Most cervico-mediastinal goiters are situated in the anterior mediastinal compartment, but according to the literature, 10-15 percent of them are located in the posterior mediastinum. Although most anterior mediastinal goiters can be removed by using the transcervical approach, cervico-mediastinal goiters in the posterior mediastinal may require additional extracervical incisions. We report the...

OBJECTIVE To assess the efficacy of 3 different treatment modalities for thyrotoxicosis and a comparison of their cost effectiveness. METHODS The case records of 100 patients treated for thyrotoxicosis at King Khalid National Guard Hospital in Jeddah were reviewed, during the period January 1992 through to January 2000. Their various treatments and responses were recorded as well as their thy...

THE MODERN surgeon approaches the surgery of thyrotoxicosis with confidence, the confidence derived from the excellence of modem anaesthesia, the euthyroid state of the patient and the knowledge that blood transfusion, antibiotics and the specific management of the occasional crisis are always available to extricate the patient from any of these complications. Though full of confidence in his o...

INTRODUCTION Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments. AIM Determination of the incidence of hypothyroidism after radioiodine treatment (I131)...

Background: Clinically solitary thyroid nodule may be defined as a goitre which on clinical examination appears to be a single nodule in an otherwise normal gland. In reality, solitary thyroid nodule is not a single disease process but a constellation of processes encountered in a variety of clinical diseases such as dominant nodule of a multi nodular goitre, true adenoma, malignancy, thyroidit...

The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D...