BACKGROUND Future European Community regulations will require a sensitive and specific assay for measurement of coeliac toxic gluten proteins in foods marketed as gluten-free. To avoid spurious cross reactions with non-toxic proteins, specific antibodies and target antigens are required. A synthetic 19 amino acid peptide of A gliadin has been shown to cause deterioration in the morphology of sm...

The active transport of toxic compounds by membrane-bound efflux proteins is becoming an increasingly frequent mechanism by which cells exhibit resistance to therapeutic drugs. This review examines the regulation of bacterial drug efflux systems, which occurs primarily at the level of transcription. Investigations into these regulatory networks have yielded a substantial volume of information t...

The SIRgene products maintain transcriptional repression at the silent mating type loci and telomeres in Saccharomyces cerevisiae, although no enzymatic or structural activity has been assigned to any of the Sir proteins nor has the role of any of these proteins in transcriptional silencing been clearly defined. We have investigated the functions and interactions of the Sir2, Sir3, and Sir4 pro...

background: due to the increasing pollution of water resources, this study was carried out for evaluation of water quality pollution indices for monitoring of heavy metals (as, zn, pb and cu) contamination in ghahavand plain, hamadan province, western iran during spring and summer 2012. methods: totally, 20 ground water wells were chosen randomly. the samples were filtered (0.45 μm) and maintai...

Intracellular bacteria use a variety of strategies to evade degradation and create a replicative niche. Legionella pneumophila is an intravacuolar pathogen that establishes a replicative niche through the secretion of more than 300 effector proteins. The function of most effectors remains to be determined. Toxicity in yeast has been used to identify functional domains and elucidate the biochemi...

seed protein quality is an important topic in the production of soybean. the quality of soybean proteins is limited by anti-nutrient proteins and low levels of essential sulfur amino acids. in this study, protein content and solubility of six cultivars were evaluated and seed storage proteins were analyzed using sds-page and scanning densitometry. the results showed that seed storage protein ba...

Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of ...