Most of the currently used toxicity assays for environmental chemicals use acute or chronic systemic or reproductive toxicity endpoints rather than neurobehavioral endpoints. In addition, the current standard approaches to assess reproductive toxicity are time-consuming. Therefore, with increasing numbers of chemicals being developed with potentially harmful neurobehavioral effects in higher ve...

Acute and chronic toxicity tests were conducted on green mussel (Perna viridis) to determine the adverse effects of lead (Pb). Exposure of organisms to acute toxicity test for 96 h and lethal concentration (LC(50)) was the endpoint of the test. Acute toxicity for 96-h LC(50) and 95% confidence intervals of P. viridis was 2.62 ± 0.12 (2.62-3.24) mg/L Pb. Chronic toxicity tests revealed that surv...

Sediments have long been recognised as a source of contaminants in marine environments and, as a result, interim sediment quality guidelines were included in the ANZECC/ARMCANZ (2000) water quality guidelines. While toxicity tests with benthic temperate species have been developed and incorporated into marine sediment toxicity assessments over the past 10 years, there has been limited test deve...

Toxicity study is the investigation of either short or long-term toxic effects of a drug or chemical on animals. The toxicity is dose-dependent as asserted by Paracelsus over 500 years ago. However, short-term toxic effect is determined using median lethal dose (LD50) first introduced by Trevan in 1927 and revised many times. Presently there is a growing preponderance of rejection of scientific...

The purpose of this study is to evaluate the acute oral toxicity Turmeric based herbal product in sprague dawley rats. Acute refers those adverse effects occurring following administration a single dose substance, or multiple doses given within 24 hours. LD50 value, defined as statistically derived that, when administered an test, expected cause death 50% treated animals period, currently basis...

A collaborative study has been carried out to establish the precision and accuracy of five test systems for the assessment of the toxicity of whole cell pertussis vaccine. To this end, six vaccines, including both "normal" and "abnormal" products with respect to arbitrary levels of Pertussis toxin and/or potency were tested. The study included in vivo test systems as the Mouse Weight Gain (MWG)...