Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were...

Teucrium Polium L. (TP) is widely used in traditional medicine of many countries including Iran. There are various reports about pharmacological properties of TP such as calcium antagonist, anti- ulcer, anti – diabetic. There are a few reports about possible toxicological effects of this plant. In the present study we designed to evaluate the subchronic toxicity of Teucrium Polium total extract...

As an example of practical observation, the basic principles forensic medical assessment therapeutic and diagnostic processes are demonstrated in case suspicion improper provision toxicological care ethylene glycol poisoning. This study highlighted factors hindering its assessment.
 Factors such as lack information from eyewitnesses or patient himself about oral intake a liquid with potent...

Toxicological data or PBPK models were not available for any of the threeor four-component submixtures. Toxicological data were available only for the binary mixture of carbon monoxide and methylene chloride; toxicological data on the other binary submixtures were not located. PBPK models for methylene chloride generally contain components describing the metabolism of methylene chloride to form...

Note: A TOXICOLOGICAL REVIEW is available for this chemical in Adobe PDF Format (153 pp, 905K). Similar documents can be found in the List of Available IRIS Toxicological Reviews. Links to specific pages in the toxicological review are available throughout this summary. To utilize this feature, your Web browser and Adobe program must be configured properly so the PDF displays within the browser...

BACKGROUND Regulatory agencies in the United Kingdom and the United States have recently issued warnings about a possible link between suicidal ideation and attempts and the use of paroxetine in a pediatric patient population. The objective of this study was to determine the proportion of youth suicides that tested positive for paroxetine or other antidepressants in medical examiner toxicologic...