نتایج جستجو برای: trabecular bone
تعداد نتایج: 308499 فیلتر نتایج به سال:
Idiopathic osteoporosis (IOP) in premenopausal women is a poorly understood entity in which otherwise healthy women have low-trauma fracture or very low bone mineral density (BMD). In this study, we applied individual trabeculae segmentation (ITS)-based morphological analysis to high-resolution peripheral quantitative computed tomography (HR-pQCT) images of the distal radius and distal tibia to...
Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits a...
While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly defined. To address its in vivo role, we constructed transgenic and pharmacologic mouse models and used peripheral quantitative computed tomography (...
BACKGROUND Osteoarthritis (OA) is now increasingly recognized as being related to the whole joint instead of the cartilage alone. In particular, the importance of subchondral bone in OA pathogenesis has drawn a lot of interest. The aim of this study is to investigate subchondral bone microstructural features in two femoral condyles of human knee osteoarthritis. METHODS Eighty subjects were en...
In this paper, we consider a stochastic anisotropic model for trabecular bone x-ray images. In [1], a fractal analysis based on isotropic Fractional Brownian Fields was proposed to characterize bone microarchitecture. However anisotropy measurement is of special interest for the diagnosis of osteoporosis [7]. We propose to model trabecular bone radiographs by operator scaling Gaussian random fi...
There are generally two types of bone tissue: trabecular and cortical. Cortical bone is the more dense tissue found on the surface of bones and trabecular bone is a highly porous structure that fills the proximal and distal ends of all long bones (e.g. femur or tibia) and is also present as a filler in other bones (e.g. in vertebral bodies). While at themolecular level both the cortical and tra...
Introduction Osteoporotic fractures of the proximal femur are very common and often result in high rates of morbidity and mortality. Most osteoporotic fractures occur at locations that are rich in trabecular bone and there is increasing evidence that the trabecular and cortical bone architecture contributes significantly to bone strength. MRI has emerged as one of the leading in vivo methods fo...
Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a boneseeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment re...
Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in IBD is understood to be a critic...
In this paper, we consider a stochastic anisotropic model for trabecular bone x-ray images. In [1], a fractal analysis based on isotropic Fractional Brownian Fields was proposed to characterize bone microarchitecture. However anisotropy measurement is of special interest for the diagnosis of osteoporosis [7]. We propose to model trabecular bone radiographs by operator scaling Gaussian random fi...
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