Chalcones share some structural similarities with GW-1929, a highly-selective and potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). In this study, we tested 53 structurally diverse chalcones to identify characteristics essential for PPARγ activation in a GAL4-based transactivation assay. This screen identified several novel chalcone agonists of PPARγ. Our results indi...

In this study, a facile and versatile procedure for the synthesis of chalcone derivate that functionalized (E,Z)-2-(4-aminobenzylidene)acenaphthylen-1(2H)-one, 4 was synthesized also characterized by using FT-IR, NMR MS. A new HPLC method separation its diastereomers developed chiral column contains amylose tris(3,5-dimethylphenylcarbamate) as selector since it is effective, reproducible can be...

Four series of novel bis-chalcone compounds with excellent performances have been synthesized and examined for the first time as photoinitiators in combination an amine iodonium salt FRP acrylates CP EPOX.

Bacterial contamination in blood product was still a problem Indonesia. Various studies to improve the safety of by inhibiting bacterial growth developed. Chalcone, is one natural compounds that has ability inhibit growth, so it can be possible use compound for anti-bacterial future. This study aim evaluate activity novel synthesis chalcone (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one agains...

Flavonoids are secondary metabolites that are present at high levels in the Polugonum minus. In recent years, flavonoids have attracted the interest of researchers because of their antioxidant properties .Flavonoids are synthesised via the condensation of 4 coumaryl-CoA and 3 malonyl-CoA by the action of Chalcone synthase. A cDNA encoding a chalcone synthase was isolated from the leaves of Poly...

Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated its inhibitory effects on endotoxin-stimulated production of reactive oxygen spec...

Chalcone synthase was isolated from both anthers of Tulipa cv. “Apeldoorn” and petals of Cosmos sulphureus Cav. After certain prepurification steps, the enzymes were further purified using gel chromatography on Sephadex G-200 followed by repeated hydroxylapatite absorption chromatography. Both the enzymes showed the same chromatographic properties. After gel chromatography as well as after the ...

Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of furanochalcones acts as MAO-B selective inhibitors. Since the effect of heterocyclic substitution, other than furan (and more recently thiophene, piperidine and quinoline) on the M...