backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by massive immune cell infiltrate, tissue destruction and extensive fibrosis. We aimed to elucidate the role of fibroblasts in pathophysiology HS. Single-cell RNA-sequencing was performed on chronic lesional samples 8 HS patients controls. Ex vivo experiments were primary dermal from lesions (n=3). Fibroblast su...

Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, high affinity iron regulon under control of transcription factor Aft1. We present evidence demonstrating that MAPK Slt2 wall integrity pathway (CWI), phosphorylates negatively regulates Aft1 activity upon de...

Expression of hepcidin, a central regulator of systemic iron metabolism, is transcriptionally regulated by the bone morphogenetic protein (BMP) pathway. However, the factors other than the BMP pathway also participate in the regulation of hepcidin expression. In the present study, we show that serum treatment increased hepcidin expression and transcription without inducing the phosphorylation o...

MYC is a target of the Wnt signalling pathway and governs numerous cellular developmental programmes hijacked in cancers. The amplification frequently occurring genetic alteration cancer genomes, this transcription factor implicated metabolic reprogramming, cell death, angiogenesis In review, we analyse gene networks solid We investigate interaction with long non-coding RNAs (lncRNAs). Furtherm...

To explore the potential molecular mechanism of Oxoglaucine(OG) in treatment Breast Cancer(BC) based on network pharmacology and bioinformatics. TCMSP SwissTargetPrediction databases search for OG Related targets, GeneCards database finds all BC-related targets. Take intersection BC as targets that inhibit BC. All are topologically analyzed by Cytoscape 3.7.1 software, finally core target is ob...

Ginkgo biloba leaves contain abundant flavonoids, and flavonoid accumulation is affected by age. MicroRNAs (miRNAs) play an important role in the plant aging pathway. However, miRNAs involved biosynthesis related to age G. have rarely been studied. In this study, we compared 1-, 4-, 7-year-old ginkgo seedings found a significant decrease content of quercetin, kaempferol, total flavonol aglycone...

Erythropoietin (EPO) exerts its effect on erythroid lineage cells through interaction with the EPO receptor (EPOR), so-called canonical pathway, and a complex consisting of EPOR common cytokine beta subunit (CD131) – non-canonical pathway for non-hematopoietic human animal body. realizes effects launch signaling cascade, which begins phosphorylation Janus kinase 2 (JAK2) then involvement phosphat...

During the fermentation process, yeast cells face different stresses, and their survival efficiency depend on adaptation to these challenging conditions. Yeast must tolerate not only a single stress but also multiple simultaneous sequential stresses. However, cellular response when are sequentially stressed completely understood. To explore this, we exposed multi-stress-tolerant strain (BT0510)...

The Hippo signaling pathway is gaining recognition as an important player in both organ size control and tumorigenesis, which are physiological and pathological processes that share common cellular signaling mechanisms. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the Yes-associated protein (YAP)/TAZ transcrip...