Development of transdermal system mainly focused on formulation and characterization of monolithic matrix type transdermal drug delivery system of diltiazem hydrochloride for the treatment of mild to moderate hypertension. In this study, seven formulations were prepared in different ratio of film forming polymers. Formulations TDDS1 to TDDS7 were composed of carboxy methyl cellulose, polyvinyl ...

Polymers are the backbone of a transdermal drug delivery system as they control the release of the drug from the device. Biodegradable polymers attracts the attention of its use as they can be degraded to non-toxic monomers and most important, a constant rate of drug release can be achieved from a biodegradable polymer based controlled release device. Natural polymers can be used as the means o...

Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can provide sustained plasma concentration profile for long periods of time. The systems can greatly improve patient compliance through avoidance of first-past metabolism, improved bioavailability, reduction of systemic side effects and dosing schedule. In the past three decades, transdermal dru...

objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...

Dear Friends, We all are well known with a fact of benefits of novel topical drug delivery systems, namely avoidance of hepatic first-pass metabolism, thus improving drug bioavailability, decreasing dosing frequency, and improving patient compliance. Regardless of the enormous investigations in topical and transdermal drug delivery systems, still stratum corneum is known as a major obstacle whi...

Transdermal therapeutic systems (TTS) belong to the widely used methods of drug administration, which allow rate-controlled drug delivery and avoidance of first-pass metabolism in the liver Beside scopolamine, nitroglycerin (glyceryl trinitrate), nicotine, clonidine and fentanyl, also transdermal delivery of sex steroids for hormone replacement therapy and contraception is a well-known and popu...