Transdermal patches loaded with pravastatin was previously characterized in another published study by Serrano-Castañeda et al; 2015. These transdermal patches (TP) were generated by the plate casting technique, the in vitro percutaneous absorption studies of TP were evaluated for three different formulations of TP with different quantities of Pluronic F-127 (PF-127): i) without PF-127 (TP W), ...

PURPOSE The one-year effectiveness of transdermal nicotine patches versus placebo patches for smoking cessation based on continuous or sustained abstinence was studied. METHODS A literature search of MEDLINE (PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials up to April 2006 was conducted. Articles containing relevant keywords were reviewed by two evaluators independentl...

There has been a continuously increased interest during recent years in the use of topical vehicle systems that can enhance drug penetration through the skin barrier into the skin or the systemic circulation. In particular, transdermal drug delivery (TDD) is an attractive alternative to conventional oral and injectable dosage forms. Since its introduction about twenty years ago, TDD has generat...

Acute mediastinitis is an uncommon and potentially devastating infection. Generally, mediastinitis occurs as a postoperative infection following median sternotomy. We describe a case of acute mediastinitis in a patient with ischaemic heart disease, secondary to the spread of cutaneous infection of the chest wall in the application site of transdermal nitroglycerine patches.

BACKGROUND The purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch. METHODS In this randomized controlled trial, women underwent either conventional IVF or intracytoplasm...

The current research aims to formulate and evaluated Cinnamaldehyde transdermal patches treat diabetes. A good penetration enhancer Oleic Acid, would improve drug delivery from various polymer-based patches. Transdermal of the matrix type were made by solvent casting techniques using polymer PVP K30, HPMC K100, solvent. All prepared formulations tested for folding endurance, weight variation, t...

Nicotine replacement by transdermal patches is more effective than placebo in smoking cessation, but has a low success rate after one year (9-18%). We tested whether this was attributed to insufficient nicotine replacement. We conducted a randomized trial to investigate the effect on outcome of different doses of transdermal nicotine replacement after stratification according to baseline plasma...

Methods The study takes place in an inpatient psychiatric unit where free, voluntary and compulsory patients mostly with DSM IVR schizophrenia and mood disorders are hospitalized. Patients facing compulsory treatment arrive in acute or very acute state, often by force, and they need a tailored smoking cessation program, combining nicotine transdermal patches, gums, but also motivational interve...

The objective of this study was to investigate the pharmacokinetics of the ligustrazine ethosome patch and antimyocardial ischemia and anti-ischemic reperfusion injury effect. Male Sprague Dawley rats were divided randomly into 3 groups: Group A (intragastric ligustrazine), Group B (transdermal ligustrazine ethosome patch), and Group C (conventional transdermal ligustrazine patch). After treatm...

INTRODUCTION: Dissolution is the required characterization test to evaluate new materials for transdermal drug delivery [1]. However the conventional dissolution tests, recommended by United State Pharmacopeia (USP), cannot provide results with good correlation with in vivo drug release, especially for patches that mainly depends on skin resistance to drug diffusion [2]. Other dissolution metho...