INTRODUCTION AND OBJECTIVES Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. METHODS The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation...

Terminal deoxynucleotidyl transferase (TdT) 1 is an enzyme which has the unique property of polymerizing deoxyribonucleotides onto a primer in the absence of a template (1-4) . Chang (4) first reported that TdT is present only in the thymus among various avian and mammalian tissues examined . Her finding was extended to humans by McCaffrey et al . (5), who found that the enzyme was restricted t...

Objective: Diabetes Mellitus (DM) is one of the leading causes of death, illness, and economic loss in the world. The present study was attempted to evaluate extract of Foeniculum vulgare (fennel) on lipid profile, lipid peroxidation and activities of amino transferase enzymes in streptozocin induced diabetic adult male rats. Materials and Methods: The effects of daily oral administration of...

The objective of this study was to investigate aspartate-amino-transferase (AST), γ-glutamyl-transferase(GGT), alkaline phosphatase (ALP), lactate-dehydrogenase (LDH) and acid phosphatase (AcP) activities andsemen parameters (volume, pH, concentration, total sperm number (TSN), progressive motility, dead sperm,total morphological defect (TMD) and hypo-osmotic swelling test (HOST)) in seminal pl...

The presence of glutathione (GSH) S-transferase activity, using 1-chloro-2, 4-dinitrobenzene (CDNB) as a substrate, has been established in the cytosolic fraction of the toxigenic (aflatoxin producing) and nontoxigenic strains of Aspergillus flavus. Significant differences in the GSH S-transferase activity were observed between the toxigenic and non-toxigenic strains. A positive correlation has...

N-acetyl transferase (NAT) is responsible to catalyze the transfer of acetyl groups to arylamines from acetyl-CoA. Aralkylamine Nacetyl transferase (AANAT), which belongs to GCN5-related N-acetyl transferase member, is a globular 23-kDa cytosolic protein that forms a reversible regulatory complex with 14-3-3 proteins, AANAT regulates the daily cycle of melatonin biosynthesis in mammals, making ...

This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alph...

Atherosclerosis is a common cardiovascular disease that involves the build-up of plaque on the inner walls of the arteries. Intraplaque neovacularization has been shown to be essential in the pathogenesis of atherosclerosis. Previous studies showed that small-molecule compounds targeting farnesyl transferase have the ability to prevent atherosclerosis in apolipoprotein E-deficient mice, but the...

Background: Margarine contain trans fatty acids as major sources of dietary free radicals, and oxidative stress. Effect of oral administration of margarine on hepatic enzyme was investigated in Wistar rats. Methods: Thirty six (36) adult Wistar rats were uniformly divided into three groups of control , margarine 15% and 20%, twelve rats in each groups (6males & 6 females). Margarine was add...

DNA polymerase mu (Polmu) is a family X member implicated in DNA repair, with template-directed and terminal transferase (template-independent) activities. It has been proposed that the terminal transferase activity of Polmu can be specifically required during non-homologous end joining (NHEJ) to create or increase complementarity of DNA ends. By site-directed mutagenesis in human Polmu, we hav...