نتایج جستجو برای: transmigration

تعداد نتایج: 1871  

2015
Katrin Neumann Ulrike Erben Nils Kruse Katja Wechsung Michael Schumann Katja Klugewitz Alexander Scheffold Anja A. Kühl Rene Lutter

Leukocyte adhesion and transmigration are central features governing immune surveillance and inflammatory reactions in body tissues. Within the liver sinusoids, chemokines initiate the first crucial step of T-cell migration into the hepatic tissue. We studied molecular mechanisms involved in endothelial chemokine supply during hepatic immune surveillance and liver inflammation and their impact ...

2013
Luigi Laviola Maura Roberta Orlando Maria Angela Incalza Cristina Caccioppoli Mariangela Melchiorre Anna Leonardini Angelo Cignarelli Federica Tortosa Rossella Labarbuta Sabina Martemucci Consiglia Pacelli Tiziana Cocco Sebastio Perrini Annalisa Natalicchio Francesco Giorgino

Endothelial cells participate in inflammatory events leading to atherogenesis by regulating endothelial cell permeability via the expression of VE-Cadherin and β-catenin and leukocyte recruitment via the expression of E-Selectins and other adhesion molecules. The protein p66(Shc) acts as a sensor/inducer of oxidative stress and may promote vascular dysfunction. The objective of this study was t...

2016
Sheng-He Huang Feng Chi Liang Peng Tao Bo Bao Zhang Li-Qun Liu Xuedong Wu Nirit Mor-Vaknin David M. Markovitz Hong Cao Yan-Hong Zhou

BACKGROUND NF-κB activation, pathogen invasion, polymorphonuclear leukocytes (PMN) transmigration (PMNT) across the blood-brain barrier (BBB) are the pathogenic triad hallmark features of bacterial meningitis, but the mechanisms underlying these events remain largely unknown. Vimentin, which is a novel NF-κB regulator, is the primary receptor for the major Escherichia coli K1 virulence factor I...

Journal: :Journal of cell science 1997
D Greiling R A Clark

After injury, the wound space is filled with a fibrin/fibronectin clot containing growth factors released by platelets and monocytes. In response to these factors, fibroblasts migrate into the fibrin clot and contribute to the formation of granulation tissue. The functional mechanisms allowing fibroblasts to leave the collagenous matrix of normal connective tissue and invade the provisional mat...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Xiaohui Zhang Aileen Chen Dina De Leon Hong Li Eisei Noiri Vincent T Moy Michael S Goligorsky

Leukocyte adhesion to vascular endothelium is a key initiating step in the pathogenesis of many inflammatory diseases. In this study, we present real-time force measurements of the interaction between monocytic human promyelocytic leukemia cells (HL-60) cells and a monolayer of human umbilical vein endothelial cells (HUVECs) by using atomic force microscopy (AFM). The detachment of HL-60-HUVEC ...

2016
SIN-HYE PARK MIN JAE SHIN DAE WON KIM JINSEU PARK SOO YOUNG CHOI YOUNG-HEE KANG

It has previously been suggested that reactive oxygen species (ROS) are involved in the pathogenesis of chronic inflammatory diseases, which entails the initial activation of pro-inflammatory cytokines to facilitate leukocyte transmigration. The present study investigated whether intracellular superoxide dismutase (SOD) suppressed monocyte endothelial trafficking and transmigration. Human umbil...

Journal: :Stem cells 2012
Grace S L Teo James A Ankrum Roberta Martinelli Sarah E Boetto Kayla Simms Tracey E Sciuto Ann M Dvorak Jeffrey M Karp Christopher V Carman

Systemically administered adult mesenchymal stem cells (MSCs), which are being explored in clinical trials to treat inflammatory disease, exhibit the critical ability to extravasate at sites of inflammation. We aimed to characterize the basic cellular processes mediating this extravasation and compare them to those involved in leukocyte transmigration. Using high-resolution confocal and dynamic...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Jennifer Lohr Thomas Ratliff Andrea Huppertz Yingzi Ge Christine Dictus Rezvan Ahmadi Stefan Grau Nobuyoshi Hiraoka Volker Eckstein Rupert C Ecker Thomas Korff Andreas von Deimling Andreas Unterberg Philipp Beckhove Christel Herold-Mende

PURPOSE In glioma-in contrast to various other cancers-the impact of T-lymphocytes on clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell infiltration in glioma. EXPERIMENTAL DESIGN T-cell subpopulations from entire sections of 93 WHO°II-IV gliomas were computationally identified using markers CD3, CD8, and Foxp3; survival analysis was then done on p...

Journal: :Journal of the Royal Asiatic Society 1909

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