Adipose tissue is a known source of proinflammatory cytokines in obese humans and animal models, including the db/db mouse, in which obesity arises as a result of leptin receptor insensitivity. Inflammatory cytokines induce cognitive deficits across numerous conditions, but no studies have determined whether obesity-induced inflammation mediates synaptic dysfunction. To address this question, w...

The current prevalence of diet-induced overweight and obesity in adolescents and adults is continuously growing. Although the detrimental biochemical and metabolic consequences of obesity are widely studied, its impact on stress-coping behavior and its interaction with specific exercise doses (in terms of intensity, duration and frequency) need further investigation. To this aim, we fed adolesc...

One of the defining characteristic of human being is their ability to walk upright. Loss or restriction of such ability whether due to the accident, spine problem, stroke or other neurological injuries can cause tremendous stress on the patients and hence will contribute negatively to their quality of life. Modern research shows that physical exercise is very important for maintaining physical ...

After a spinal hemisection in cats, locomotor plasticity occurring at the spinal level can be revealed by performing, several weeks later, a complete spinalization below the first hemisection. Using this paradigm, we recently demonstrated that the hemisection induces durable changes in the symmetry of locomotor kinematics that persist after spinalization. Can this asymmetry be changed again in ...

The purpose of this study was to compare the effectiveness of high-intensity interval training such as Billat 30s-30s training (HIIT) vs moderate intensity endurance training (CT+HIIT) on aerobic parameters in young adults men. The study involved 40 young adults men (20,15±0,56 years) who were randomly divided into the two training groups: Billat 30s working at 100% of vVO2max and 30s recovery ...

Foot drop and toe walking are frequent concerns in children with cerebral palsy. The main underlying cause of these problems is early damage and lack of maturation of the corticospinal tract. In the present study we investigated whether 4 weeks of daily treadmill training with an incline may facilitate corticospinal transmission and improve the control of the ankle joint in children with cerebr...

www.thelancet.com Published online August 11, 2016 http://dx.doi.org/10.1016/S0140-6736(16)31347-2 1 Falls are a leading cause of morbidity and mortality in older adults. Studies conducted in Europe, the USA, and Australia show that roughly a third of communityliving people aged 65 years or older fall at least once per year, with half of this number having multiple falls in this period. Falls i...

How to repair the injured spinal cord is a question that scientists have struggled with for decades. The answer is of course still a mystery. But ask people on the street for their opinion and they will likely offer something like “stem cells” as the solution. I find it amusing (and honestly, a bit annoying) that family and friends continue to ask me if there is anything new with stem cells. My...

In a recent study competitive road cyclists experienced substantial gains in sprint and endurance performance when sessions of high-intensity interval training were added to their usual training in the competitive phase of a season. The current study reports the effect of this type of training on performance of 20 distance runners randomized to an experimental or control group for 5 to 7 weeks ...

OBJECTIVE To determine whether providing a controlled resistance versus assistance to the paretic leg at the ankle during treadmill training will improve walking function in individuals poststroke. DESIGN Repeated assessment of the same patients with parallel design and randomized controlled study between 2 groups. SETTING Research units of rehabilitation hospitals. PARTICIPANTS Patients ...