Diabetic rats in long-term display an augmented nociceptive response to chemical, mechanical, and thermal stimuli. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of chard, this study was carried out to evaluate the possible analgesic effect of chard-mixed food intake in male streptozotocin-induced diabetic r...

Objective(s): In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effectson the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in ratand to explore the underlying mechanism. Materials and Methods: Rats were treated with Aβ1-42 and dox...

Background and Objective: Lowering serum glucose and lipid levels in diabetic patients by using natural materials is of great importance. In this study, the effect of oral consumption of Fumaria Parviflora Lamwas was assessed on serum glucose and lipid levels in streptozocin diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar rats were divided into four groups of co...

Abstract Diabetes mellitus (DM) is a disease caused due to high blood sugar levels. Treatment for patients can be supported through suitable diet and nutrition intake. One of the potential plants used in diabetic pumpkin (Cucurbita moschata) which contains numerous bioactive compounds such as fiber, beta-carotene, phenolic compounds. This study was conducted determine effect substitution feedin...

Objective(s):Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. Materials and Methods: The effects of VBL treatment on motor, learning and memory functions of male and female Wistar rats were studied by behavioral related tests. Animals were given chro...

background: diabetes mellitus has a variety of structural and functional effects on the male reproductive system. diabetes results in reduced sperm parameters and libido. the present study aims to investigate the effects of royal jelly (rj) on reproductive parameters of testosterone and malondialdehyde (mda) production in diabetic rats. materials and methods: this experimental study was conduct...

background: it is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. the aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (htn) rats. methods: experiments were performed...

Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days peri...

objective(s):diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (tgf-β). fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent tgfβ1 modulator. in this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...