نتایج جستجو برای: treatment initiation timing
تعداد نتایج: 1545714 فیلتر نتایج به سال:
Background and Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common drugs prescribed for controlling and post root canal treatment pain. During the last decade, a new generation of NSAIDs has been introduced such as Celecoxib and Gelofen with less gastrointestinal side effects and more analgesic effect. No studies have been performed to compare Celecoxib and Gelofen with oth...
BACKGROUND When to initiate antiretroviral therapy in HIV infected patients is a difficult clinical decision. Actually, it is still a matter of discussion whether early highly active antiretroviral therapy (HAART) during primary HIV infection may influence the dynamics of the viral rebound, in case of therapy interruption, and overall the main disease course. METHODS In this article we use a ...
AIMS To estimate the magnitude of genetic and environmental influences on timing of first alcohol use and alcohol dependence (AD) and to quantify the overlap in these influences across the two alcohol-related outcomes. PARTICIPANTS The sample consisted of 5382 twins (2691 complete pairs), aged 24-36 years, from the Australian Twin Registry. MEASUREMENTS History of alcohol use and DSM-IV alc...
PURPOSE Early pubertal timing is associated with early initiation of cigarettes and alcohol; we evaluated parental monitoring and affiliation with deviant peers in a moderated, mediational model of this relationship for both genders. METHODS We tested a prospective model explaining the process through which pubertal timing is related to early use of cigarettes and alcohol for 360 fourth and f...
Both male/female patients with Fabry disease (FD) may receive enzyme replacement therapy (ERT). Previously published analyses of the Fabry Outcome Survey (FOS; Shire-sponsored) database suggested gender differences in timing of ERT initiation. We assessed alignment of criteria for ERT initiation in the Spanish adult population included in FOS with recommendations of a Spanish national consensus...
initiation of renal replacement therapy (RRT) in decreasing mortality and ICU length of stay in patients with Acute Kidney Injury Network stage 3 [1]; however, we have a few concerns regarding the study. e impact of fl uid balance on morbidity and mortality in patients with septic shock, especially with acute kidney injury, cannot be understated [2]. is impact can aff ect ventilator-free days a...
INTRODUCTION Combination antiretroviral therapy (ART) significantly decreases morbidity, mortality and HIV transmission. We aimed to characterize the timing of ART initiation based on CD4 cell count from 2000 to 2012 and identify factors associated with late initiation of treatment. METHODS Participants from the Canadian Observational Cohort (CANOC), a multi-site cohort of HIV-positive adults...
Background There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. Methods A total of 20 576 antiretroviral treatment (ART)-naïve patients, aged 1-16 years at enrolment, from 19 cohorts in Europe, Southern Africa and West Africa, were included. We compared mortality and growth outcomes for different ART initiation criteria,...
The bacterial replication cycle is driven by the DnaA protein which cycles between the active ATP-bound form and the inactive ADP-bound form. It has been suggested that DnaA also is the main controller of initiation frequency. Initiation is thought to occur when enough ATP-DnaA has accumulated. In this work we have performed cell cycle analysis of cells that contain a surplus of ATP-DnaA and as...
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