Modafinil (Provigil) is a medication used to promote wakefulness. Originally marketed in 1998, modafinil, a Schedule C-IV drug, was approved by the Food and Drug Administration (FDA) for the treatment of excessive sleepiness (ES) associated with narcolepsy. In 2003, the FDA approved modafinil for the treatment of ES associated with obstructive sleep apnea-hypopnea syndrome (only as an adjunct t...

OBJECTIVE To perform a meta-analysis of antidepressant-antipsychotic cotreatment versus antidepressant or antipsychotic monotherapy for psychotic depression. DATA SOURCES We performed an electronic search (from inception of databases until February 28, 2011) in PubMed/MEDLINE, Cochrane Library, and PsycINFO, without language or time restrictions. Search terms were (psychosis OR psychotic OR h...

AIM Measure efficacy of eicosapentaenoic acid (EPA) in children with attention deficit hyperactivity disorder (ADHD). METHODS Randomized controlled trial (RCT) of 0.5 g EPA or placebo (15 weeks) in 92 children (7-12 years) with ADHD. Efficacy measure was Conners' Parent/Teacher Rating Scales (CPRS/CTRS). Fatty acids were analysed in serum phospholipids and red blood cell membranes (RBC) at ba...

ISSN 1868-0844 ISBN 978-3-86956-262-9 Seit den 60er Jahren gibt es im deutschsprachigen Raum Diskussionen um die Begriffe Schlüsselqualifikation und (Schlüssel-) Kompetenz, welche seit ca. 2000 auch in der Informatikdidaktik angekommen sind. Die Diskussionen der Fachdisziplinen und ihre Bedeutung für die Informatikdidaktik sind Gegenstand des ersten Teils dieser Dissertation. Es werden Rahmenmo...

BACKGROUND Electrical stimulation (ES) shows promising results in increasing healing of decubitus ulcers. Recent studies show that skin blood flows (SBFs) are enhanced if the subject is exposed to a warm environment during treatment. The purpose of this investigation was to determine if blood flow would increase with ES in a physically active older population without wounds in a warm environmen...

Mast cell infiltration of tumour islets represents a survival advantage in non-small cell lung cancer (NSCLC). The phenotype and activation status of these mast cells is unknown. We investigated the mast cell phenotype in terms of protease content (tryptase-only [MCT], tryptase + chymase [MCTC]) and tumour necrosis factor-alpha (TNFα) expression, and extent of degranulation, in NSCLC tumour str...

This paper investigates the behavior of PSO (particle swarm optimization) and CMA-ES (covariance matrix adaptation evolution strategy) on ill-conditioned functions. The paper also highlights momentum as important common concept used in both algorithms and reviews important invariance properties. On separable, ill-conditioned functions, PSO performs very well and outperforms CMA-ES by a factor o...

this study was conducted at the gorgan university of agricultural sciences and natural resources farm, iran, golestan province with about 600 mm annual rainfall in order to evaluate the effect of different sowing dates on azivash (corchorusolitorius) seed quality, using a randomized complete block design with three replications on 2013. treatments were four sowing dates such as may 5, jun 5, ju...

Stem cell therapy holds great promise for the replacement of damaged or dysfunctional myocardium. Nitric oxide (NO) has been shown to promote embryonic stem (ES) cell differentiation in other systems. We hypothesized that NO, through NO synthase gene transfer or exogenous NO exposure, would promote the differentiation of mouse ES cells into cardiomyocytes (CM). In our study, NO treatment increa...