Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune...

Abstract The prevalence of vitiligo is estimated to be between 0.5% and 2.0% globally, with marked geographical differences. Patients may burdened by comorbidities a lack satisfactory treatment. UK evidence on the vitiligo-associated burden disease healthcare resource utilization lacking. aged ≥ 12 years were identified using data from administrative databases (Clinical Practice Research Datali...

BACKGROUND Vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. The exact etiology and pathogenesis of vitiligo is not clear. Many theories have been presented regarding this subject among them aautoimmune theory is the most important one. The association of vitiligo with other autoimmune disorders has been reported, but the relationship b...

INTRODUCTION Several therapeutic options are available for the treatment of vitiligo; among these phototherapy and topical steroids are the most widely documented. A topical formulation of 0.05% clobetasol propionate foam (CPF) has been introduced in the market, but no data are available about the efficacy and tolerability of this new formulation in the treatment of vitiligo. The aim of this st...

The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled and received combination therapy for 12 weeks. The condition of the ski...

conclusions: nigella sativa oil and fish oil were effective in reduction the size of patient’s lesions; however, nigella sativa was more effective in comparison to the fish oil. therefore, using nigella sativa with the major drugs in the treatment of vitiligo is recommended. background: vitiligo is one of the autoimmune skin diseases that destroy the melanocytes of the skin. moreover, its preva...

Progressive Childhood vitiligo is a common acquired de-pigmenting condition that can affect skin and hair with devastating psychological effects on patients as well as their parents. Children with vitiligo often suffer from anxiety and depression because of their unusual appearance. Management of progressive vitiligo in children is difficult as therapeutic options are restricted when compared t...

Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was...

Vitiligo is a common chronic skin depigmentation disorder. affects about 1% of population in world and characterized by depigmented patches from which melanocytes (melanin producing cells) have been lost. There are different types vitiligo, the most type non-segmental generalized that widely distributed, usually symmetric, progressive lesions. has great impact on physical mental health patients...

Obviously, vitiligo is a multifactorial disease, and at this stage, we all accept that the autoimmune theory, the adhesion defect theory and the biochemical theory based on oxidative stress are the mainstays of our current knowledge about the aetiology of the disease. The presence of an imbalance in the anti-oxidant system in vitiligo melanocytes was assessed early, providing support for a free...