background: investigation was designed to evaluate the behavioral changes in children receiving dental treatment while they have been administered combination of midazolam/ketamine or midazolam/promethazine. materials and methods: this was a randomized double blind clinical trial with cases being selected from those uncooperative children aged 2 to 6 years from those referred for treatment unde...

A prospective, open, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of the conventional four-drug combination (chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline) with that of doxycycline alone in oral maintenance treatment of melioidosis. Adult Thai patients with culture-confirmed melioidosis were randomized to receive treatment with eith...

INTRODUCTION Ledipasvir/sofosbuvir (LDV/SOF) for hepatitis C virus (HCV) treatment provides an oral interferon-free treatment regimen with high rates of sustained virologic response (SVR). This study assessed treatment discontinuation, factors associated with treatment completion, and real-world effectiveness. METHODS Patients with HCV treated with LDV/SOF between October 2014 and June 2015 a...

BACKGROUND Adverse drug reactions are a major concern with zidovudine/stavudine treatment regimens. The less toxic tenofovir regimen is an alternative, but is seldom considered due to the higher costs. This study compared adverse drug reactions and other clinical outcomes resulting from the use of these two treatment regimens in India. METHODS Baseline, clinical characteristics and follow-up ...

Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of treatment. The current recommendation is a four-drug regimen (trimethoprim [TMP], sulfamethoxazole [SMX], doxycycline, and chloramphenicol) and a total treatment time of 12 to 20 weeks. Drug side effect...

Second line antiretroviral therapy (ART) regimen is used when patients fail their first line regimen. There are many factors such as non-adherence, drug resistance as well as virological and immunological failure that lead to second line highly active antiretroviral therapy (HAART) regimen treatment failure. This study was aimed at determining predictor factors to treatment failure with second ...

From 1991 to 1992, 15 patients with atopic dermatitis were treated with a new UVB treatment regimen guided by skin reflectance measurements. The new treatment was characterized by very low dose increments from start to end of therapy. The median cumulative dose increment during therapy was only 20%. The severity of the disease, the efficacy of the treatment, the occurrence of adverse effects an...

Aim . To study adherence to recommended treatment, additional clinical and economic benefits of a titration-free statin therapy regimen. Material methods Ambulatory patients (n=300) with high or very risk hypercholesterolemia who have indications for treatment primary secondary prevention cardiovascular diseases is included in non-randomized trial. Patients are divided into 2 groups. Group 1 ha...

Enfortumab vedotin (EV) is an antibody drug conjugate for patients with locally advanced or metastatic urothelial carcinoma. Clinical trials evaluating the efficacy of EV have reported treatment-related rash in 43.9% patients. There insufficient data characterizing cutaneous adverse events (CAEs) associated this medication. We sought to characterize CAEs from including type reaction, patient de...