Let dn = Pn+i ~Pn denote the nth gap in the sequence of primes. We show that for every fixed integer A; and sufficiently large T the set of limit points of the sequence {(dn/logra, ■ • • ,dn+k-i/logn)} in the cube [0, T]k has Lebesgue measure > c(k)Tk, where c(k) is a positive constant depending only on k. This generalizes a result of Ricci and answers a question of Erdös, who had asked to prov...

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular tr...

Critical Limb Ischemia as a Public Health Crisis Peripheral artery disease (PAD) is one of the most common cardiovascular diseases and is associated with high short-term morbidity and mortality. It is the primary cause of lower extremity amputation throughout the world and is a powerful marker of advanced systemic atherosclerosis. Chronic critical limb ischemia (CLI) represents the most advance...