BACKGROUND Down syndrome is one of the most important causes of mental retardation in the population. In the absence of prenatal screening and diagnosis, prevalence at birth in the United States would currently exceed 1:600. The purpose of prenatal screening is to identify those women at the increased risk for an affected pregnancy and to maximize the options available to these women. TESTS A...

The aim of this study was to determine the role of N-linked glycosylation in protein stability, intracellular trafficking, and bile acid transport activity of the bile salt export pump [Bsep (ATP-binding cassette B11)]. Rat Bsep was fused with yellow fluorescent protein, and the following mutants, in which Asn residues of putative glycosylation sites (Asn(109), Asn(116), Asn(122), and Asn(125))...

BACKGROUND Low success rates with triple therapy for Helicobacter pylori infections have prompted search for alternatives. In one, a proton-pump inhibitor (PPI) and amoxicillin was followed by the PPI plus clarithromycin and a nitroimidazole (sequential therapy); in another, these four drugs were given concomitantly (concomitant therapy). AIM To compare concomitant therapy with standard tripl...

The purpose of this paper is to review the biomechanics of triple and quadruple figure skating jumps, focusing on information that has implications for strength and conditioning programs. At a minimum, to complete the required revolutions in a jump, a skater must balance the average angular velocity with the time in the air. Vertical velocity at takeoff is similar in high revolution jumps to th...

In this paper, we first show that for any fixed D(−1)-triple {1, b, c} with b < c, there exist at most two d’s such that {1, b, c, d} is a D(−1)-quadruple with c < d. Using this result, we further show that there exist at most 10 D(−1)-quadruples. AMS subject classifications: 11D09, 11D45

Helicobacter pylori infection is one of the most common human infections which have been associated with many upper gasterointestinal complications. Different treatment regimens for Helicobacter pylori eradication have been used. One of these regimes is the quadruple therapy regimen which metronidazole is one of the medications. In recent years several reports on H. pylori res...

background: in developing countries primary antibiotic-resistance and poor compliance are the main causes of helicobacter pylori (hp) eradication failure of standard regimens. aim: to investigate eradication rate, patient's compliance and tolerability of a 1-wk azithromycin based quaruple therapy versus the 2-wk conventional therapy. materials and methods: a total of 129 hp-positive patients we...

A blocking quadruple (BQ) is a quadruple of vertices of a graph such that any two vertices of the quadruple either miss (have no neighbours on) some path connecting the remaining two vertices of the quadruple, or are connected by some path missed by the remaining two vertices. This is akin to the notion of asteroidal triple used in the classical characterization of interval graphs by Lekkerkerk...

We have devised a novel 1,3-benzdiyne equivalent, capable of quadruple functionalization by sequential benzyne generation and reaction with arynophiles. The key features of this method include the chemoselective generation of two triple bonds in a single benzene ring under fluoride-mediated mild conditions, and the regiocontrol of each benzyne reaction by the substituent next to the triple bond...

Auxiliary basis sets for density fitting second-order Moller-Plesset perturbation theory (DF-MP2) have been optimized for use with the triple-zeta nonrelativistic all-electron correlation consistent orbital basis sets, cc-pVTZ-NR and aug-cc-pVTZ-NR, for the 3d elements Sc-Zn. The relative error in using these auxiliary basis sets is found to be around four orders of magnitude smaller than that ...