BACKGROUND To assess the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor-2 (HER2) neu receptor in breast cancer and their associations with various clinicopathological characteristics. MATERIALS AND METHODS This is a retrospective analysis of women who presented with primary, unilateral breast cancer in the Depar...

Comparative studies on the clinical features and outcomes of triple-negative subgroups to human epidermal growth factor receptor-2 (HER-2) overexpression, and luminal A and B subgroups in lymph node-negative breast cancer patients, are important to correctly evaluate clinical prognosis. A total of 1132 Chinese breast cancer patients were enrolled in a retrospective analysis. We characterized an...

The most lethal damage for the cell among all damage is double-strand breaks (DSB) of DNA. DSB cause development of cancer diseases including the triple-negative molecular subtype of breast cancer. The aim of this work was to evaluate the single nucleotide polymorphism -135G>C (rs1801320) of the RAD51 gene encoding DNA repair proteins by homologous recombination (HR) in triple-negative breast c...

A folic acid-erythrocyte membrane bioengineered fluorescent covalent organic framework was developed for synergistic treatment of triple-negative breast cancer through starvation/NO gas/immunization therapy.

BACKGROUND Results from epidemiologic studies on the relationship between vitamin D and breast cancer risk are inconclusive. It is possible that vitamin D may be effective in reducing risk only of specific subtypes due to disease heterogeneity. METHODS AND FINDINGS In case-control and case-series analyses, we examined serum concentrations of 25-hydroxyvitamin D (25OHD) in relation to breast c...

Triple-negative breast cancer is associated with poor prognosis because of a high rate of tumor recurrence and metastasis. Previous studies demonstrated that the synthetic triterpenoid, CDDO-Imidazolide (CDDO-Im) induced cell cycle arrest and apoptosis in triple-negative breast cancer. Since a small subpopulation of cancer stem cells has been suggested to be responsible for drug resistance and ...

Breast cancer is a big challenge for universal public health and has made as nuisance for every people who suffered from this disease. It is the second most common cause of cancer-related deaths in women worldwide. Triple-negative breast cancer (TNBC) is an advanced multi-drug resistance (MDR) breast cancer which affect majority of women worldwide Bakrania et al. [1]. TNBC is distinct by the la...

Breast cancer is a big challenge for universal public health and has made as nuisance for every people who suffered from this disease. It is the second most common cause of cancer-related deaths in women worldwide. Triple-negative breast cancer (TNBC) is an advanced multi-drug resistance (MDR) breast cancer which affect majority of women worldwide Bakrania et al. [1]. TNBC is distinct by the la...

Breast cancer is a big challenge for universal public health and has made as nuisance for every people who suffered from this disease. It is the second most common cause of cancer-related deaths in women worldwide. Triple-negative breast cancer (TNBC) is an advanced multi-drug resistance (MDR) breast cancer which affect majority of women worldwide Bakrania et al. [1]. TNBC is distinct by the la...

AIM The role of protein kinase D (PKD) in the context of breast cancer cell biology is not clear. MATERIALS AND METHODS The expression of PKD isoforms was assessed in various breast cancer cell lines and PKD isoform-specific siRNAs and selective inhibitors were used to study the role of PKD in breast cancer cell growth. RESULTS PKD2 and PKD3 were two major isoforms expressed at the highest ...