BACKGROUND The prognostic importance of elevated cardiac enzymes after elective percutaneous coronary intervention has been debated. Therefore, we performed a prospective observational study to evaluate the prognostic value of postprocedural rise of troponin T and creatine kinase. METHODS Troponin T (cut-off value 0.05 ng/ml) and creatine kinase (cut-off value 180 IU/l with muscle-brain fract...

BACKGROUND New-generation high-sensitivity assays for cardiac troponin have lower detection limits and less imprecision than earlier assays. Reference 99th-percentile cutoff values for these new assays are also lower, leading to higher frequencies of positive test results. When cardiac troponin concentrations are minimally increased, serial testing allows discrimination of myocardial infarction...

BACKGROUND To test the hypothesis that troponin I and echocardiography have an incremental prognostic value in patients with pulmonary embolism (PE). METHODS AND RESULTS In 91 patients with acute PE, echocardiography was performed within 4h of admission. Troponin I levels were obtained on admission and 12h thereafter. The 0.06 microg/l troponin I cut-off level was identified as the most usefu...

BACKGROUND Clinicians face uncertainty about the prognostic value of troponin testing in patients with chronic kidney disease (CKD) without suspected acute coronary syndrome (ACS). PURPOSE To systematically review the literature on troponin testing in patients with CKD without ACS. DATA SOURCES MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through May 2014. STUDY...

Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in at least 8 contractile protein genes, most commonly b myosin heavy chain, myosin binding protein C, and cardiac troponin T. Affected individuals are heterozygous for a particular mutation, and most evidence suggests that the mutant protein acts in a dominant-negative fashion. To investigate the functional properties of a trunc...

Aims Heart failure may occur following acute myocardial infarction, but with the use of high-sensitivity cardiac troponin assays we increasingly diagnose patients with minor myocardial injury. Whether troponin concentrations remain a useful predictor of heart failure in patients with acute coronary syndrome is uncertain. Methods and results We identified all consecutive patients (n = 4748) wi...

OBJECTIVE It was supposed that troponins in cardiac myxoma patients might be in a same fashion as in the conditions without myocardial injury. In order to verify this hypothesis, troponins in cardiac myxoma patients were discussed by presenting a comprehensive retrieval of the literature with incorporating the information of a recent patient. METHODS Postoperative detections of troponin I, cr...

to improve the specificity of biochemical markers of myocardial infarction (mi) a method to measure cardiac troponin-i (ctn-i) was developed. ctn-i is a protein unique to cardiac muscle and is released after mi. consecutive 150 patients admitted to the coronary care unit was studied. value of ctn-i was determined in all samples. ctn-i concentration in the mi patients group was increased compare...

background: the cardioprotective effect of ischemic preconditioning has been known for many years. since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ischemic preconditioning (ripc). we hypothesized that the extension of ripc has more cardioprotective effect in patients undergo...

A high incidental rise in cardiac troponin I carries a higher mortality risk in older patients than in those with a diagnosed acute coronary syndrome SIR—Cardiac troponins are highly sensitive and specific biomarkers for myocardial injury [1]. Furthermore, in the context of an acute coronary syndrome (ACS), baseline elevations of troponin have prognostic significance, with a higher risk of deat...