Fragile histidine triad (FHIT) serves a critical function as a tumor suppressor that inhibits p53 degradation by mouse double minute 2 (MDM2). The functional domains of FHIT involved in tumor inhibition was interpreted. In-silico screening data were employed to construct truncated forms of FHIT to assess their cytotoxic effects on the HT1080 cell line. Full FHIT expression was confirmed by west...

The skew-Laplace distribution has been used for modelling particle size with point observations. In reality, the observations are truncated and grouped (rounded). This must be formally taken into account for accurate modelling, and it is shown how this leads to convenient closed-form expressions for the likelihood in this model. In a Bayesian framework, “noninformative” benchmark priors, which ...

This paper introduces Chain sampling plan for generalized exponential distribution when the life-test is truncated at a prespecified time are provided in this manuscript. It is assumed that the shape parameter of the generalized exponential distribution is known. The design parameters such as the minimum sample size and the acceptance number are obtained by satisfying the producer’s and consume...

Zipf’s law appears in many application areas but does not have a closed form expression, which may make its use cumbersome. Since it coincides with the truncated version of the Zeta distribution, in this paper we propose three approximate closed form expressions for the truncated Zeta distribution, which may be employed for Zipf’s law as well. The three approximations are based on the replaceme...

Truncated Midzuno-Sen Sampling Schemes for Estimating Distribution Functions Sarjinder Singha; Jong-Min Kimb; Hakjin Jangc; Stephen Hornd a Department of Mathematics, Texas A&M University-Kingsville, Kingsville, Texas, USA b Division of Sciences and Mathematics, University of Minnesota-Morris, Morris, Minnesota, USA c Division of Applied Mathematics, Hanyang University, Ansan, Korea d Departmen...

Abstract In this article we present tmvtnorm, an R package implementation for the truncated multivariate normal distribution. We consider random number generation with rejection and Gibbs sampling, computation of marginal densities as well as computation of the mean and covariance of the truncated variables. This contribution brings together latest research in this field and provides useful met...

We propose truncated and power-transformed (TPT) models for daily rainfall and we derive the Generalized Extreme Value (GEV) limit distributions for these models. We find that these limit distributions belong to the domain of attraction of the Fréchet family when the parent distribution of the daily values is a TPT t-Student model. In this case the shape parameter of the limiting GEV model depe...