نتایج جستجو برای: tryptophan synthase

تعداد نتایج: 99594  

2017
Cara Godee Mohamed M. Mira Owen Wally Robert D. Hill Claudio Stasolla

Mutation of phytoglobin 2 (Pgb2) increases the number of somatic embryos in Arabidopsis. To assess the effects of the cellular localization of Pgb2 on embryo formation, an inducible system expressing a fusion protein consisting of Pgb2 linked to the steroid-binding domain of the rat glucocorticoid receptor (GR) was introduced in a pgb2 mutant line lacking the ability to express Pgb2. In this tr...

Journal: :Angewandte Chemie 2016
Javier Murciano-Calles David K Romney Sabine Brinkmann-Chen Andrew R Buller Frances H Arnold

Naturally occurring enzyme homologues often display highly divergent activity with non-natural substrates. Exploiting this diversity with enzymes engineered for new or altered function, however, is laborious because the engineering must be replicated for each homologue. A small set of mutations of the tryptophan synthase β-subunit (TrpB) from Pyrococcus furiosus, which mimics the activation aff...

2014
Bethany G. Caulkins Baback Bastin Chen Yang Thomas J. Neubauer Robert P. Young Eduardo Hilario Yu-ming M. Huang Chia-en A. Chang Li Fan Michael F. Dunn Michael J. Marsella Leonard J. Mueller

The acid-base chemistry that drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been the subject of intense interest and investigation since the initial identification of PLP's role as a coenzyme in this extensive class of enzymes. It was first proposed over 50 years ago that the initial step in the catalytic cycle is facilitated by a protonated Schiff base form of the holoe...

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