Eastern Nigeria presents today a situation of great interest as concerns the relationship of leprosy to tuberculosis. Leprosy is declining rapidly while tuberculosis is increasing, and if there is any truth in the hypothesis that the retreat of one disease is induced by the advance of the other, circumstances are now unfolding in which it should be possible to demonstrate the facts. Against thi...

OBJECTIVE Tuberculosis (TB) is an important infectious disease worldwide. Tuberculin skin test (TST) is the standard test for diagnosis of tuberculosis infection; Bacillus Calmette-Guerin (BCG) vaccination at birth has effects on this test. The aim of this study was to determine the prevalence of positive TST cases among 7- to 11-year-old primary school children and also to follow test-positive...

Seibert (1930) found that the tuberculin proteins of the three varieties of tubercle bacillus could be distinguished by the precipitin test. If this method could be adapted for identifying tubercle bacilli, it would be preferable to animal inoculation. The behavior of the tuberculin proteins of acid-fast bacteria in the precipitin test is interesting not only as a possible means of identificati...

Ireland currently obtains its avian and bovine tuberculin purified protein derivatives (PPDs) from a single source. Because problems of supply or quality cannot be discounted, it is prudent that Ireland identify alternative supplier(s) as part of a broad risk management strategy. Therefore, the aim of this study was to compare the performance of a number of different tuberculin combinations (th...

This study was aimed at investigating the immunologic relationship between cytokine production pattern and tuberculin negativity in patients with active Mycobacterium tuberculosis infection. After classifying patients by the extent of pulmonary involvement and the size of the tuberculin reaction, we evaluated the rate of cytokine positivity in peripheral blood to determine whether there is a ch...

CONTEXT Budgetary constraints in tuberculosis (TB) control programs require streamlining contact investigations without sacrificing disease control. OBJECTIVE To develop more efficient methods of TB contact investigation by creating a model of TB transmission using variables that best predict a positive tuberculin skin test among contacts of an active TB case. DESIGN, SETTING, AND SUBJECTS ...

In vivo and in vitro properties of the Transfer Factor (TF) and Migration Inhibition Factor (MIF) obtained from 2,4-dinitrofluorobenzene (2,4-DNFB) and tuberculin systems were studied simultaneously. Purified fractions of TF and MIF were obtained by Geon-Pevikon block electrophoresis and Sephadex G-200 exclusion chromatography. The physical and biological properties of these purified fractions ...

BACKGROUND M. tuberculosis remains one of the world's deadliest pathogens in part because of its ability to establish persistent, latent infections, which can later reactivate to cause disease. In regions of the globe where disease is endemic, as much as 50% of the population is thought to be latently infected, complicating diagnosis and tuberculosis control. The tools most commonly used for di...

Lopes L.B., Alves T.M., Stynen A.P.R., Mota P.M.P.C., Leite R.C. & Lage A.P. 2012. Parameter estimation and use of gamma interferon assay for the diagnosis of bovine tuberculosis in Brazil. Pesquisa Veterinária Brasileira 32(4):279-283. Embrapa Agrossilvipastoril, Rodovia MT 222, km 2,5, Caixa Postal 343, Sinop, MT 78.550-970, Brazil. E-mail: [email protected] This study aimed to evaluat...