The insulin-like growth factor I receptor is known to play a major role in transformation and apoptosis. The dominant negative mutant of the insulin-like growth factor I receptor, designated 486/STOP, causes massive apoptosis of tumor cells and inhibition of tumor growth and metastases. We now show that: (a) the stable expression of 486/STOP inhibits transformation (colony formation in soft aga...

BACKGROUND Cell-based therapy has been implicated in the treatment of liver diseases. Mesenchymal stem cells from various sources such as bone marrow are available. These cells are one of the major candidates in cell therapy. The production of insulin-like growth factor-I increases in the regenerating organ. The insulin-like growth factor-I in liver regeneration is effective after binding to in...

Despite the significant improvement in treatment modalities, cancer is one of fastest-growing chronic disease conditions all over world. Genetic and Epigenetic alterations normal physiology cell are key factor for tumor development. These changes can trigger production abnormal protein expressions through stimulation different signaling pathways deeply affect growth proliferation. Any altered e...