Large Tumor Therapy In article number 2203227, Yanyu Huang, Liangping Luo, Zeyu Xiao, and co-workers report a localized radioimmunotherapeutic regimen by using X-ray irradiation metal-cyclic dinucleotide-containing nanomodulator for the treatment of large tumors. This combined paradigm amplifies STING signaling pathway elevating production 2′,3′-cGAMP activating both systematic anti-tumor immun...

Introduction: Tumor-based molecular profiling has increased in the area of precision medicine. Their routine use is still limited by accessibility, cost and availability tumor material. Materials Methods: We retrospectively analysed treatment received survival data patients with digestive cancer who high-throughput sequencing (NGS) analyses at diagnosis. The primary objective this single-center...

introduction: photodynamic therapy is a noninvasive therapeutic method for tumors with a maximum depth of 5 mm. on the other hand, most photosensitizers are also susceptible to ultrasound waves (the basis of sonodynamic therapy). therefore, it is expected that a combination of the two therapeutic methods will increase effectiveness of photodynamic therapies for lower doses of sensitizer and cur...

<p style='text-indent:20px;'>We investigate a mathematical model of tumor–immune system interactions with oncolytic virus therapy (OVT). Susceptible tumor cells may become infected by viruses that are engineered specifically to kill cancer but not healthy cells. Once the destroyed oncolysis, they release new infectious particles help surrounding The immune constructed includes innate and ...

Tumor heterogeneity is commonly seen in melanoma patients and a hurdle to effective therapy as illustrated by the “mixed responses” frequently immunotherapy-treated patients. Previously, AXL+ cells were identified be highly resistant targeted therapy, whereas more differentiated MITF+ responded well RAF/MEK inhibitors. This study aimed identify if show intrinsic resistance immunotherapy, these ...

background: study in design to incorporate accelerated proliferation correction factors into linearquadratic and multiple-component models. materials and methods: accelerated proliferation rate correction factor has been incorporated into the linearquadratic and the multiple component models by applying accelerated exponential cell growth to explain the tumor cell kinetics and estimates proper ...

Tumor Immunotherapeutic Gels In article number 2204273, Dunfang Zhang, Hang Zhao, and co-workers demonstrate that an inosine-based supramolecular hydrogel, IPBisoG, can achieve the gradual sequential release of inosine aPDL1. Inosine, which enhancs proliferation function CD8+ T cells, together with aPDL1, blocker immunosuppressive pathway in tumor microenvironment, could highly enhance vivo eff...

Purpose: The paper reviews the obstacles that face CAR-T cells in solid tumors and suggested novel strategies to overcome these association with efficacy as well safety profile of cell therapy. Subjects Methods: This is a systematic review exploring improve tumors. Results: Several have been developed, including: 1) targeting multiple antigens; 2) improving trafficking into tumor tissues; 3) Pr...

The treatment landscape of metastatic castration-resistant prostate cancer (mCRPC) has dramatically improved over the last decade; however, patients with visceral metastases are still faced poor outcomes. Phosphatase and tensin homolog ( PTEN ) loss is observed in 40%–60% mCRPC also associated a prognosis. Several PI3K/AKT/mTOR pathway inhibitors have been studied, disappointing anti-tumor acti...