Homer represents a new and diversified family of proteins made up of several isoforms. The presence of Homer isoforms, referable to 1b/c and 2a/b, was investigated in fast- and slow-twitch skeletal muscles from both rat and mouse. Homer 1b/c was identical irrespective of the muscle, and Homer 2a/b was instead characteristic of the slow-twitch phenotype. Transition in Homer isoform composition w...

Not only twitch torque but also the maximal voluntary concentric torque increases after a high-intensity contraction (conditioning contraction). The purpose of this study was to test the hypothesis that the increase in the maximal voluntary concentric torque induced by a conditioning contraction is prominent when tested at fast angular velocities conditions. Twelve healthy male participants per...

Skeletal muscle mass declines with age, as does the potential for overload-induced fast-twitch skeletal muscle hypertrophy. Because 5'-AMP-activated protein kinase (AMPK) activity is thought to inhibit skeletal muscle protein synthesis and may therefore modulate muscle mass and hypertrophy, the purpose of this investigation was to examine AMPK phosphorylation status (a marker of AMPK activity) ...

Talent Identification in the field of exercise science is growing exponentially, where muscle considered as most reliable method for determining fiber type and selecting sports activity accordingly. Muscle architecture a new determination technique now trend, which refers to macroscopic arrangement fibres that influences muscle's mechanical function. Previous research has shown relationship bet...

Rabbit predominantly fast-twitch-fibre and predominantly slow-twitch-fibre skeletal muscles of the hind limbs, the psoas, the diaphragm and the masseter muscles were fibre-typed by one-dimensional polyacrylamide-gel electrophoresis of the myofibrillar proteins of chemically skinned single fibres. Investigation of the distribution of fast-twitch-fibre and slow-twitch-fibre isoforms of myosin lig...

Calorie restriction (CR) induces enhanced insulin-stimulated glucose uptake in fast-twitch (type II) muscle from old rats, but the effect of CR on slow-twitch (type I) muscle from old rats is unknown. The purpose of this study was to assess insulin-stimulated glucose uptake and phosphorylation of key insulin signaling proteins in isolated epitrochlearis (fast-twitch) and soleus (slow-twitch) mu...

BACKGROUND Skeletal muscle twitch responses may be transiently increased by previous contractions, a phenomenon termed twitch potentiation. The aim of this study was to examine the extent and time course of diaphragmatic twitch potentiation and its relationship to both the magnitude and duration of the preceding voluntary diaphragmatic contraction. METHODS Twitch transdiaphragmatic pressure (...

We aimed to determine the neuronal parameters controlling the contraction of slowly contracting, non-twitch ("tonic") muscles driven by rhythmic neuronal activity. These muscles are almost completely absent in mammals but are common in lower vertebrates and invertebrates. Slow muscles are often believed to function primarily in tonic motor patterns. However, previous research and data presented...

Actomyosin ATPase is the dominant ATP sink during muscle work. Its catalytic capacities in fast-twitch oxidative glycolytic fibers have long been known to exceed by about 3-fold those of slow-twitch oxidative fibers, but the relative contributions to control of metabolic rates during exercise have never been closely examined. We compared fast-twitch oxidative glycolytic and slow-twitch oxidativ...