The poster provides an overview of the cadherin superfamily, depicting representative molecules for several subfamilies, and displaying the plethora of molecular arrangements characteristic of these molecules (see Commentary by Angst, Marcozzi and Magee on p. 629). Classical cadherins form lateral dimers and typically mediate homophilic adhesion between neighbouring cells and linkage to the act...

Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see Laudet and Gronemeyer, 2002). Nuclear hormone receptors function as ligandactivated transcription factors, and thus provide a direct link between signaling molecules that con...

Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors therapeutic interest. GPCRs considered to be highly tractable for drug discovery, representing targets approximately one-third currently licensed drugs. These successful discovery outcomes cover only a relatively small subset superfamily, however, and many other attractive have proven present significant c...

The HAD (haloacid dehalogenase) superfamily includes phosphoesterases, ATPases, phosphonatases, dehalogenases, and sugar phosphomutases acting on a remarkably diverse set of substrates. The availability of numerous crystal structures of representatives belonging to diverse branches of the HAD superfamily provides us with a unique opportunity to reconstruct their evolutionary history and uncover...