Cryptococcus neoformans is a haploid environmental organism and the major cause of fungal meningoencephalitis in AIDS patients. Fluconazole (FLC), a triazole, is widely used for the maintenance therapy of cryptococcosis. Heteroresistance to FLC, an adaptive mode of azole resistance, was associated with FLC therapy failure cases but the mechanism underlying the resistance was unknown. We used co...

Candida tropicalis has emerged as an important pathogenic fungus in nosocomial infections due to its recalcitrant resistance to conventional antifungal agents, especially to fluconazole (FLC). Berberine (BBR) is a bioactive herbal-originated alkaloids and has been reported to possess antifungal functions against C. albicans. In this paper, we tried to figure out the antifungal mechanisms of BBR...

In Arabidopsis thaliana, flowering-time variation exists among accessions, and the winter-annual (late-flowering without vernalization) versus rapid-cycling (early flowering) growth habit is typically determined by allelic variation at FRIGIDA (FRI) and FLOWERING LOCUS C (FLC). FRI upregulates the expression of FLC, a central floral repressor, to levels that inhibit flowering, resulting in the ...

Exposure to short-term cold stress delays flowering by activating the floral repressor FLOWERING LOCUS C (FLC) in Arabidopsis thaliana. The cold signaling attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (HOS1) negatively regulates cold responses. Notably, HOS1-deficient mutants exhibit early flowering, and FLC expression is suppressed in the mutants. However, it remains unknown how H...

The photoinduced alignment of ferroelectric liquid crystals (FLCs) onto photochemically stable azo-dye films was studied. The alignment quality of FLC display cells depends mainly on the difference between the FLC surface energy and the aligning substrates surface energy; however, the structure and thickness of FLC layers are also important. The effect of the thickness of photoaligning azodye l...

Vernalization promotes flowering in Arabidopsis through epigenetic repression of the floral repressor, FLOWERING LOCUS C (FLC). Vernalization, like other polycomb-mediated repression events, occurs in two stages; FLC repression is established at low temperatures, then maintained during subsequent growth at 22 degrees C. Low temperatures induce VIN3 activity, which is required for changes in his...

This paper examines the size reduction of the fuzzy rule base without compromising the control characteristics of a fuzzy logic controller (FLC). A 49-rule FLC is approximated by a 4-rule simplest FLC using compensating factors. This approximated 4-rule FLC is implemented to control the shunt active power filter (APF), which is used for harmonic mitigation in source current. The proposed contro...

forming limit curve (flc) is an important tool for evaluation of formability of sheet metals subjected to different loading. free bulge of aluminume tubes has been investigated numerically to obtain flc. to verify the numerical results one experimental setup has been manufactured which has the ability of controlling the internal pressure and axial feed. in this study, time and zone of bursting ...

For more than 150 years, the presence of Bence Jones protein [immunoglobulin free light chains (FLCs)] in the urine has been an important diagnostic marker for multiple myeloma. Indeed, it was the first cancer test, and 100 years before any others (1 ). Over the last few years, however, interest in FLCs has undergone a renaissance. Development of serum tests for free and free has opened the doo...

An optimal semi-active Cuckoo- Fuzzy algorithm is developed to drive the hydraulic semi-active damper for effective control of the dynamic deformation of building structures under earthquake loadings, in this paper. Hydraulic semi-active dampers (MR dampers) are semi active control devices that are managed by sending external voltage supply. A new adaptive fuzzy logic controller (FLC) is introd...