Islet amyloid has been suggested to be an important link between insulin resistance and beta-cell dysfunction in type 2 diabetes. To investigate the prevalence and clinicopathological characteristics of islet amyloid, we examined consecutive autopsies of 235 Chinese patients with type 2 diabetes and 533 nondiabetic subjects. Islet amyloid deposits were identified using Congo red staining and qu...

The localization of gold in the synovial membrane of rheumatoid arthritis patients treated with sodium aurothiomalate was examined and quantitative analysis of epon-embedded sections was carried out with a wavelength dispersive x-ray microanalyser. Gold was only detected in the lysosomes of synovial lining type A cells and subsynovial mononuclear cells in the form of filamentous deposits and hi...

We show evidence that the primary uranium minerals, uraninite and coffinite, from high-grade ore samples (U3O8N0.3%) in the Wuyiyi, Wuyier, and Wuyisan sandstone-hosted roll-front uranium deposits, Xinjiang, northwestern China were biogenically precipitated and psuedomorphically replace fungi and bacteria. Uranium (VI), which was the sole electron acceptor, was likely to have been enzymically r...

In the Sierra Nevada, the “Recess Peak Glaciation” has been previously defined on the basis of deposits exhibiting relative-age characteristics intermediate between those of the Little Ice Age deposits and those of early Holocene or older moraines. In the absence of reliable chronological control, the Recess Peak deposits were assigned an early Neoglacial age. Although numerous moraines in the ...

Introduction: Eolian sedimentary deposits are important because they provide a record of the direction and strength of winds on Mars and the type and flux of sediments transported by the winds. While Martian sand dunes and transverse aeolian ridges ("TARs") have been thoroughly studied, the sedimentary deposits left behind by blowing dust have received comparatively little attention to date. Wi...

Two morphological types of prion protein (PrPsc) deposit occur in the cerebral cortex of cases of variant Creutzfeldt-Jakob disease (vCJD), viz., diffuse and florid deposits. The objective of this study was to determine whether diffuse-type PrPsc deposits in areas of the cerebral cortex in six cases of the variant form of CJD (vCJD) were spatially correlated with neurons and whether diffuse dep...

Hepatic venous catheterisation and transvenous liver biopsy were performed in five patients with hepatic amyloidosis. In three patients, hepatic venous pressures were normal and histological examination of the liver biopsy specimen showed discrete and sparse perisinusoidal amyloid deposits. In the other two, however, the gradient between wedged and free hepatic venous pressures was increased (1...

Most rare earth element deposits form from magmatic fluids, but there have also been discoveries of heavy rare earth element (HREE)– enriched hydrothermal xenotime deposits within sedimentary basins. As xenotime is notoriously insoluble, the question arises as to whether these lesser-known deposits form at typical basin temperatures or by influx of much hotter magmatic-hydrothermal fluids. The ...

determining the promising area for ore deposits is one of the most important steps of prospecting in regional scales. there are many different methods for identifying these areas including geochemical and geophysical methods, remote sensing and sophisticated statistical methods. based on the theory of spatial relations between the dispersion pattern of ore deposits and metallogenic provinces, m...

BACKGROUND The extracellular matrix proteoglycans decorin and biglycan may have a pathogenic role in renal fibrosing disease via regulation of the activity of growth factors, such as transforming growth factor-beta, and effects on collagen type I fibrillogenesis. The expression of decorin and biglycan in human glomerular diseases characterized by mesangial sclerosis is unknown. METHODS Decori...