for the first time in the present study the effects of vanillin, vanillyl alcohol, vanillic acid, as well as the newly synthesized vanillin derivative, bis-vanillin, were investigated on the oxidation of dopamine hydrochloride by mushroom tyrosinase. among them, vanillin and bis-vanillin act as activators, while vanillyl alcohol and vanillic acid exhibited inhibitory effects, the ic50 values be...

For the first time in the present study the effects of vanillin, vanillyl alcohol, vanillic acid, as well as the newly synthesized vanillin derivative, bis-vanillin, were investigated on the oxidation of dopamine hydrochloride by mushroom tyrosinase. Among them, vanillin and bis-vanillin act as activators, while vanillyl alcohol and vanillic acid exhibited inhibitory effects, the IC50 values be...

Melanogenesis is the process of melanin synthesis and distribution by a cascade of enzymatic and chemical reactions in melanocytes. The role of melanin is to protect the skin from the harmful effects of ultraviolet light and scavenging free radicals. However, increased levels of epidermal melanin synthesis can darken the skin and produce various dermatologic disorders, such as melasma, age spot...

gen oxidoreductase, EC 1.14.18.1) is a copper-dependent protein widely distributed in nature. The enzyme catalyzes two different reactions: the hydroxylation of monophenols to o-diphenols (monophenolase activity) and the oxidation of odiphenols to o-quinones (diphenolase activity), both utilizing molecular oxygen. The enzymatic browning of fruits and vegetables is mostly related to the oxidatio...

Tyrosinase enzymes (Tys) are involved in the key steps of melanin (protective pigments) biosynthesis and molecules targeting binuclear copper active site on tyrosinases represent a relevant strategy to regulate enzyme activities. In this work, possible synergic effect generated by combination known inhibitors is studied. For this, derivatives containing kojic acid (KA) 2-hydroxypyridine-N-oxide...

(UV) light-induced skin damage. On the other hand, overexposure to UV radiation can lead to a pathological increase in melanin production. Epidermal hyper-pigmentation results from the increased activity of melanogenic enzymes such as tyrosinase. Tyrosinase oxidizes the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and DOPA to DOPA quinone, which are the first two rate limiting ...

Skin hyperpigmentation is a biological process that results in an excess production of melanin. Tyrosinase inhibition effective approach to this condition, although inhibitors reported the literature lack clinical efficacy or show toxic effects. Chalcone derivatives are well known tyrosinase but insoluble aqueous phase limiting its use final product formulations. The aim study develop new chalc...