The conserved vacuolar protein-sorting (Vps) pathway controls the trafficking of proteins to the vacuole/lysosome. Both the internalization of ubiquitylated cargo from the plasma membrane and its sorting at the late endosome via the Vps pathway depend on ubiquitin (Ub) binding motifs present in trafficking regulators. Here we report that Ub controls yet a third step in the Vps pathway. Vps9p, w...

MHC class I proteins mediate a variety of functions in antiviral defense. In humans and mice, three MHC class I loci each contribute one or two alleles and each can present a wide variety of peptide Ags. In contrast, many lower vertebrates appear to use a single MHC class I locus. Previously we showed that a single locus was predominantly expressed in the mallard duck (Anas platyrhynchos) and t...

Continuous K nearest neighbor queries (C-KNN) are defined as finding the nearest points of interest along an entire path (e.g., finding the three nearest gas stations to a moving car on any point of a pre-specified path). The result of this type of query is a set of intervals (or split points) and their corresponding KNNs, such that the KNNs of all points within each interval are the same. The ...

Positive and negative selection of thymocytes in the thymus are critical for the development of a mature and self-tolerant T-cell repertoire. The proapoptotic Bcl-2 family member Bim is important for negative selection by inducing apoptosis in thymocytes receiving a strong signal through their antigen receptor. However, in the case of ubiquitous self-antigens (UbA), Bim is not required for the ...

Successful change detection in multi-temporal images relies on high spatial co-registration accuracy. However, co-registration accuracy alone cannot meet the needs of change detection when using several ground control points to separately geo-reference multi-temporal images from unmanned aerial vehicles (UAVs). This letter reports on a new approach to perform bundle adjustment—named united bund...