We have synthesized a biomaterial consisting of Gd(III) ions chelated to lipid-coated, size-selected microbubbles for utility in both magnetic resonance and ultrasound imaging. The macrocyclic ligand DOTA-NHS was bound to PE headgroups on the lipid shell of pre-synthesized microbubbles. Gd(III) was then chelated to DOTA on the microbubble shell. The reaction temperature was optimized to increas...

Sonophoresis can increase skin permeability to various drugs in transdermal drug delivery. Cavitation is recognized as the predominant mechanism of sonophoresis. Recently, a new logical approach to enhance the efficiency of transdermal drug delivery was tried. It is to utilize the engineered microbubble and its resonant frequency for increase of cavitation activity. Actively-induced cavitation ...

Interest in microbubbles as agents for therapeutic and quantitative imaging applications in biomedical ultrasound has increased the need for their accurate modelling. However, effects such as gas diffusion, the properties of the shell and changes in bubble behaviour under repeated exposure to ultrasound pulses are still not well understood. A revised equation for microbubble motion is proposed ...

Rheumatoid arthritis (RA) is an autoimmune disease characterized by severe inflammation of the synovial tissue. Here, we assess feasibility liposome-loaded microbubbles as theranostic agents in a murine model. First, contrast-enhanced ultrasound (CEUS) was used to quantify neovascularization this model since CEUS well-established for RA diagnosis humans. Next, potential and (US) selectively enh...

This review discusses the development, current applications, and therapeutic potential of ultrasound contrast agents. Microbubbles containing gases act as true, intravascular indicators, permitting a noninvasive, quantitative analysis of the spatial and temporal heterogeneity of blood flow and volumes within the microvasculature. These shelled microbubbles are near-perfect reflectors of acousti...

Time-resolved dynamics of nonspherical oscillations of micrometer-sized bubbles are captured and analyzed using high-speed imaging. The axisymmetry of the bubble shape is ensured with certainty for the first time from the recordings of two synchronous high-speed cameras located at 90^{∘}. The temporal dynamics of finite-amplitude nonspherical oscillations are then analyzed for various acoustic ...