Introduction. The purpose of this study was to demonstrate the frequency and severity of nonmotor symptoms and their correlations with a wide range of demographic and clinical factors in a large cohort of patients with Parkinson's disease (PD). Methods. 268 PD patients were assessed using the validated Movement Disorders Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the Beck D...

b a c k ground: several studies have indicated that executive dysfunction is the main neuropsychological feature of parkinson’s disease (pd). the frontal assessment battery (fab) is a short tool for the assessment of executive functions. p u r p o s e : the aim of this study was to determine the relationship between persian version of fab scores and age, education, mini-mental state examination...

Abstract Nowadays, smart health technologies are used in different life and environmental areas, such as life, healthcare, cognitive cities, social systems. Intelligent, reliable, ubiquitous healthcare systems a part of the modern developing technology that should be more seriously considered. Data collection through ways, Internet things (IoT)-assisted sensors, enables physicians to predict, p...

BACKGROUND The optimal design and outcome measures for preventive clinical trials in neurodegenerative diseases are unknown. OBJECTIVE To examine measures that may be associated with disease in the largest cohort ever recruited of prediagnosed individuals carrying the gene expansion for Huntington disease (HD). DESIGN The Predict-HD study is a multicenter observational research study in pro...

OBJECTIVE The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide guidance on scale selection in Parkinson disease (PD). METHODS Patients with PD (n = 229) from community-based neurology practices completed 6 self-report scales (Beck Depression Inventory [BDI]-II, Center for Epidemiologic Studies...

Objective: The Methods of Optimal Depression Detection in Parkinson’s Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide guidance on scale selection in Parkinson disease (PD). Methods: Patients with PD (n 229) from community-based neurology practices completed 6 self-report scales (Beck Depression Inventory [BDI]–II, Center for Epidemiologic Studies D...

BACKGROUND Pedunculopontine nucleus (PPN) stimulation is a novel therapy for Parkinson disease. However, controversies remain regarding the clinical application of this new therapy, including patient selection, electrode positioning, and how best to assess outcomes. OBJECTIVE To clarify the clinical application of PPN stimulation in Parkinson disease. METHODS Five consecutive patients with ...