OBJECTIVES Polycystic ovary syndrome is associated with insulin resistance and obesity. Previous studies suggest that metformin by reducing hyperinsulinemia is clinically useful in the treatment of polycystic ovary syndrome. This study's Objective is to observe the role of metformin in omentin1, ghrelin, and other biochemical, clinical features within three months in hyperinsulinemic women with...

Background: There is a close relationship between hormones, oxidative stress, and inflammatory factors polycystic ovary syndrome (PCOS). This meta-analysis was conducted to evaluate the changes in of PCOS patients who were supplemented with omega-3 polyunsaturated fatty acids (n-3 PUFAs).

background: polycystic ovary syndrome (pcos) is one of the most common reproductive disorders in women. previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of pcos. objectives: in the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of test...

background: increasing attention to the concept of polycystic ovary syndrome (pcos) health-related quality of life has led to the development of tool that aims to measure this concept. objective: the purpose of this study was to conduct a systematic review of psychometric properties of the pcos health-related quality of life questionnaire. materials and methods: a search of database (pubmed, ps...

background: chromium picolinate could be effective in clomiphen citrate resistant pcos patients. objective: to compare the effects of chromium picolinate vs. metformin in clomiphen citrate resistant pcos patients. materials and methods: the present randomized clinical trial was performed on 92 women with clomiphen citrate-resistant pcos at the clinics which were affiliated to shiraz university ...

background: polycystic ovary syndrome (pcos) is the most common endocrinopathy affecting up to one in every five women of reproductive age. the majority of researches on pcos focus on its biomedical aspects, often overlooking and neglecting women’s own perceptions and experiences. objectives: this study aimed to explore women’s perception and experiences that influence their personal gender rol...

background: polycystic ovary syndrome (pcos) is one of the common endocrine disorders in women of reproductive ages. it is associated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (ir), compensatory hyperinsulinemia,gestational, and type 2 diabetes, and increased risk of cardiovascular morbidity. there are different treatments available for pcos. the purpose ...

background: insulin resistance has an important role in pathophysiology of polycystic ovarian syndrome (pcos). yet there are certain controversies regarding the presence of insulin resistance in non-obese patients. objective: the aim was to compare the insulin resistance and various endocrine and metabolic abnormalities in obese and non-obese pcos women.materials and methods: in this cross-sect...

background: gap-junctional intercellular communication (gjic) is implicated in physicological processes and it is vitally important for granulosa cell (gc) differentiation and oocyte growth. we investigated the expression of connexin 43 (cx43), a gap junctional protein, in normal and androstenedione-induced polycystic ovary (pco), the effects of androstenedione on cx43 expression, gjic and prog...

In 1935 Stein and Leventhal described seven hirsute and infertile women with amenorrhoea or oligomenorrhoea in whom bilateral cystic ovarian enlargement was found at laparotomy' and thereby gave their names to a polycystic ovarian disorder. Since then, however, the protean manner of clinical presentation and the variability of biochemical changes in patients with this condition have led some pe...