Competition binding and UV melting studies of a DNA model system consisting of three, four or five mutually complementary oligonucleotides demonstrate that unpaired bases at the branch point stabilize three- and five-way junction loops but destabilize four-way junctions. The inclusion of unpaired nucleotides permits the assembly of five-way DNA junction complexes (5WJ) having as few as seven ba...

Methods 143 JoAS were compared with 413 AoAS patients attending a secondary care rheumatology hospital. A diagnosis of AS was made using the 1987 modified New York criteria. The following clinical parameters were recorded: sex; age at symptom onset (JoAS only); age at Rheumatologist-made diagnosis; the most recent BASFI, BASDAI, BASMI; HLA-B27 genotype status; the occurrence at any time point o...

Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Figure 1. Starvation decreases mosquito lipid reserves. The total amount of lipids in the female body significantly increased...

To determine if there is a gender difference in the resource consumption activities of students in Central Mindanao University, a Philippine state university, an ecological foot printing study was conducted in August 2014. Consumption data from 380 student respondents were gathered using a survey questionnaire. A web-based software created by the Global Footprint Network was used to convert the...

Materials and Methods: A randomised, prospective, and double-blind study was conducted in 60 American Society of Anaesthesiologists Grade I and II patients of age between 18 and 65 years,either gender, scheduled for various surgeries under spinal anaesthesia. The patients were randomised in two groups of 30 patients each to receive either dexmedetomidine 0.5 μg/kg or tramadol 0.5 mg/kg as a slo...

FIGURE 1. Effect 0fGDPBS, CTP.,S, and GTP on 3H-mucin release. Confluent cultures (16 mm) which had been pretreated with streptolysin 0 were pulsed with H-glucosamine for 24 h and chased for 30 mm in the presence of the nucleotides (200 p.M GTP.,S, 200 iM GDP,,S, and 200 M GTP). In panel A, GDP,,S was added immediately before GTP S. Data represent means ± SE of4 culture dishes. Mucin release by...

Based on a variational approach, we propose that there are two kinds of low-energy states in the t-J-type models at low doping. In a quasiparticle state an unpaired spin bound to a hole with a well-defined momentum can be excited with spin waves. The resulting state shows a suppression of antiferromagnetic order around the hole with the profile of a spin bag. These spin-bag states with spin and...

The anatomy and histology of the unpaired ventral nerves are described from lightand electron-microscopical studies. Seven unpaired nerves arise from the median dorsal surface of the ventral ganglionic nerve-mass, and terminate in abdominal segments 2 to 8 respectively. Each unpaired nerve bifurcates, sending a lateral nerve to both sides of its respective segment. Subsequently the lateral nerv...

The Drosophila JAK-STAT pathway and its ligand Unpaired are required for a wide range of developmental processes. Recent results have identified Unpaired as an activator of sex-lethal and revealed a new role for the JAK-STAT pathway in sex determination.

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to motor neuron dysfunction resulting in impairment of neuromuscular transmission. A2A adenosine receptors have already been considered as a potential therapeutical target for ALS but their neuromodulatory role at the neuromuscular junction in ALS remains to be clarified. In the present work, we evaluated the effects of ...