I NTEREST in urethane (NH2’CO.OC2H5) and related carbamic acid esters in the treatment of metastatic malignant tumors and leukemias has been greatly stimulated by the report of Haddow and Sexto& on the effects of urethane on tumors in experimental animals, and of Paterson, Haddow, Thomas and Watkinson2 on urethane therapy of human leukemias and malignant tumors. They demonstrated striking decre...

The bismuth-catalyzed urethane reaction is significantly accelerated by generating heterobimetallic mixtures of bismuth and lithium carboxylates.

Propolis is a natural agent produced by honeybees from several botanical sources. The purpose of our study to evaluate the antitumor effect propolis extract (PE) against urethane-induced lung cancer compared Cisplatin (CIS) in rats. Some biochemical parameters oxidative stress, gene expression and histopathology transmission electron microscopy were estimated performed. PE improved induced chan...

This study assessed the effect of the molecular structure of newly synthesized methacrylate monomers on their chemical stability in human saliva, whereby these monomers can be used as dental composite resins. Six model monomethacrylates and two urethane-modified BisGMA monomers were added to human saliva, and their change in concentration after 24, 48, and 72 hours were measured by high-perform...

We describe a novel slow oscillation in intracellular recordings from cortical association areas 5 and 7, motor areas 4 and 6, and visual areas 17 and 18 of cats under various anesthetics. The recorded neurons (n = 254) were antidromically and orthodromically identified as corticothalamic or callosal elements receiving projections from appropriate thalamic nuclei as well as from homotopic foci ...

The autonomic nervous system plays an important role in rat anaphylactic hypotension. It is well known that sympathetic nerve activity and cardiovascular function are affected by anesthetics. However, the effects of different types of anesthesia on the efferent renal sympathetic nerve activity (RSNA) during anaphylactic hypotension remain unknown. Therefore, we determined the renal sympathetic ...

Olfactory bulb granule cells are activated synaptically via two main pathways. Mitral/tufted (M/T) cells form dendrodendritic synapses on granule cells that can be activated by antidromic stimulation of the lateral olfactory tract (LOT). Centrifugal fibers originating from the association fiber (AF) system in piriform cortex (PC) make axodendritic synapses on granule cells within the granule ce...

The rostral ventrolateral medulla (RVLM) contains neurons involved in tonic and reflex control of arterial pressure. We describe the effects of gamma-aminobutyric acid (GABA) and anesthetics injected into the RVLM of conscious and urethane (1.2 g/kg, iv) anesthetized Wistar rats (300-350 g). In conscious rats, bilateral microinjection of GABA (50 nmol/200 nl) induced a small but significant dec...

New biodegradable multiblock amphiphilic and thermosensitive poly(ether ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] (PHB), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG) blocks were synthesized, and their aqueous solutions were found to undergo a reversible sol-gel transition upon temperature change at very low copolymer concentrations. The multiblock poly(ether es...

it is well established that the esophageal distention (ed) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ed on gastric acid secretion has not been investigated. the aim of this study was to investigate the effect of ed on basal and stimulated gastric acid secretion. methods: adult male wistar rats (200-240 g) were deprived of food but not the water 24 h b...