In spite of vast improvements in urinary stone treatment (ESWL, PNL, ureteroscopy, etc.), metabolic workup concerning the existence of stone forming risk factors are of great importance and can lead to control and even prevention of urinary stone formation in these patients. In this analytical case-control study performed on 266 persons [110 normal persons (56 males and 54 females), 76 pat...

OBJECTIVE To assess the prevalence of the main metabolic alterations found in patients with recent diagnosis of urolithiasis in the West region of Parana state, Brazil. MATERIALS AND METHODS We made a retrospective study on 425 patients with evidence of recent formation of renal stones. Laboratory assessment consisted in 3 samples of 24-hour urine with dosing of calcium, uric acid, citrate, o...

Since the first report in 2005, Roux-en-Y gastric bypass (RYGB) surgery has been linked to a variety of metabolic changes that alter kidney stone risk. The studies with the highest level of evidence, performed in non-stone forming patients before and after RYGB, cite a number of kidney stone risk factors, including a 25% increase in urinary oxalate, a 30% decrease in urinary citrate, and reduct...

INTRODUCTION: H NMR spectroscopy coupled with pattern recognition methods is being widely used in the classification of biomedical data from biofluids. Urine analysis by NMR is used in the study of inborn errors of metabolism, kidney transplant rejection, urinary tract infection, cancer of organs such as bladder and kidney, and toxicology [1]. There are several experimental conditions that can ...

PURPOSE To access the effect of repeated extracorporeal shock wave (ESW) on urinary biochemical markers METHODS 20 rats were assigned for ESW (Direx Tripter X1(R) - 14 KV) to one of two groups: G1 (n=10) one ESW; G2 (n=10) two ESWs within a 14-day interval. Within the twenty-four hour period before and after the application of shock waves, the animals were placed in metabolic cages for 24 hou...

BACKGROUND A simple and reliable method is needed to assess disease activity and monitor the efficacy of therapy in polymyositis (PM) and dermatomyositis (DM). This study used in vitro proton ((1)H) magnetic resonance spectroscopy (MRS) to explore whether excretion of urinary metabolites can be used as a reliable marker of disease in PM and DM patients. METHODS Urine samples were obtained fro...

Vanadium pentoxide is used as a catalyst and a ferrovanadium alloy ingredient in automotive steels and in jet engines and airframes. In addition, vanadium is found in fuel oils. Thus, occupational exposures to vanadium pentoxide and trioxide may occur during the cleaning of oil-fired ship boilers, and from oil-fired power station boilers. Occupational exposure to vanadium pentoxide induces gree...

Commentary Definitive evidence of how best to prevent CIN is lacking despite numerous studies. Markota and colleagues found that 5 g of oral Na/K citrate given 1 hour before coronary angiography and then 4 hours later resulted in a 17% absolute risk reduction in CIN at 48 hours after catheterization. Post hoc analysis showed a 93% relative risk reduction (RRR) in CIN in patients with urinary pH...