Renal cell carcinoma (RCC) accounts for about 3% of all human malignancies and its incidence is increasing. There are no standard biomarkers currently used in the clinical management of patients with renal cell carcinoma. A promising strategy for new biomarker detection is comparative proteomics of urinary exosomes (UE), nanovesicles released by every epithelial cell facing the urinary space, e...

Renal involvement is a frequent consequence of plasma cell dyscrasias. The most common entities are light chain amyloidosis, monoclonal immunoglobulin deposition disease and myeloma cast nephropathy. Despite a common origin, each condition has its own unique histologic and pathophysiologic characteristic which requires a renal biopsy to distinguish. Recent studies have shown urinary exosomes co...

objective(s):psoriasis is an autoimmune disease that appears on the skin. although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. the aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human to find valuable biomarkers. materials and methods: in a case-control s...

cancer has been always in a great attention in the field of molecular biology. by applying    large-scale tools such as advanced proteomics, cancer diagnosis and treatment have been improved greatly since. cancers of esophagus, gastric, and colon accounted for major health problem globally. biomarker panel could bring out the accuracy for cancer evaluation tests as it can suggest a group of can...

information avalanche (overload or expansion) in various scientific fields is a novel issue turned out by a number of factors considered necessary to facilitate their record and registration. though, the biological science and its diverse fields like proteomics are not immune of this event and even may be as the event’s herald. on the other hand, time as the most valued anxiety of human has enc...

Abstract Diet can directly affect colon health and cancer risk. For example, the polyphenolic ellagitannins (punicigalin) that are present in walnuts converted by microbiome to a panel of bioactive urolithin metabolites. In particular, A has been studied for its anti-inflammatory anti-cancer properties. this pilot clinical trial, we evaluate effects walnut consumption (2-oz per day) on urinary ...

Inflammation plays a key role in coronary artery disease (CAD) and other manifestations of atherosclerosis. Recently, urinary proteins were found to be useful markers for reflecting inflammation status of different organs. To identify potential biomarker for diagnosis of CAD, we performed one-dimensional SDS-gel electrophoresis followed by liquid chromatography coupled with tandem mass spectrom...

different treatment strategies of alzheimer's disease (ad) are being studied for treating or slowing the progression of ad. many pharmaceutically important regulation systems operate through proteins as drug targets. here, we investigate the drug target proteins in beta-amyloid (aβ) injected rat hippocampus treated with lavandula angustifolia (la) by proteomics techniques. the reported stu...