Epigenetic mechanisms have been shown to play a role in alcohol use disorders (AUDs) and may prove to be valuable therapeutic targets. However, the involvement of histone deacetylases (HDACs) on alcohol-induced oxidative stress of human primary monocyte-derived dendritic cells (MDDCs) has not been elucidated. In the current study, we took a novel approach combining ex vivo, in vitro and in sili...

Alcohol, with its impact on both communicable and non-communicable diseases, is considered as the third global public health priority. Alcohol ranked third among causes of ill health and premature death, and ranked second in terms of cost among all the substances of abuse, after tobacco, even though nearly half the world’s population drinks alcohol. In most countries, where alcohol is considere...

In fact alcohol is a toxic substance that has a direct effect on brain. Some of the most common mental disorders due to alcohol abuse are: Memory disorder: Hazardous amounts of alcohol may cause intoxication, impairment of memory so that the person who took a drunken accident may not remember the event. Periods of memory impairment in those with a history of alcohol addiction would also happen ...

Background: World Health Organization report in 2014 indicates a considerable range of alcohol consumption across the world which had a growing trend during last 5 years. A study on 5,231 students in 57 universities has shown that alcohol consumption became more common than other drugs, and alcohol is in the first rank for repeated usage. In another study in 2010, the prevalence of alcohol use ...

within the country , there is evidence of the prevalence of alcohol consumption among young people and students. the major purpose of the present study was to investigate social science faculty of tehran university students’ attitude toward alcohol consumption and to explain this attitude from rational choice theory perspective. the method of this research was survey and the data collection ins...

Abstract Background: This study investigated the epidemiology of drug abuse among high school students in Kerman. Methods: This was a cross-sectional study on a randomly selected sample of 652 first and second grade high school students (256 boys, 396 girls) in Kerman. They were informed that their answers would be classified and nameless before they filled questionnaires. Schools and ...

Adolescent solitary drinking may represent an informative divergence from normative behavior, with important implications for understanding risk for alcohol-use disorders later in life. Within a self-medication framework, we hypothesized that solitary alcohol use would be associated with drinking in response to negative affect and that such a pattern of drinking would predict alcohol problems i...