PURPOSE To establish polyhexamethylene biguanide (PHMB) as an effective treatment for Aspergillus keratitis in a novel murine model. To determine the ability of the calcineurin inhibitors tacrolimus (FK506) and cyclosporine A (CSA) to enhance the activity of PHMB, amphotericin B (AMB), and voriconazole (VCZ) against Aspergillus keratitis. METHODS IN VITRO STUDIES Broth antifungal susceptib...

STUDY OBJECTIVE To determine the relationship between aspergillus recovery from the airways of lung transplant recipients and the development of endobronchial abnormalities. DESIGN Retrospective case series. SETTING Tertiary-care hospital. PATIENTS All patients who underwent lung transplantation between December 1991 and June 1999. MEASUREMENTS AND RESULTS The study cohort included 38 p...

background: aspergillus species are associated with allergic bronchopulmonary disease, mycotic keratitis, otomycosis, na­sal sinusitis and invasive infection. in this study, we developed a pcr-single strand confomational polymorphism method to identify the most common aspergillus species and we showed some advantages of this method comparing a pcr-restric­tion fragment length polymorphism with ...

a 46- year–old man with pulmonary tuberculosis which had treated with ant tuberculosis drugs was referred to medical mycology laboratory, school of public health and institute of public health research for coughing and bloody sputum. chest x-ray revealed a cavern with a moveable mass in right apical lobe. direct examination of sputum showed wide septated dichotomous hyphae and aspergillus fumig...

background: introduction of the rna interference (rnai) machinery has guided the researchers to discover the function of essential vital or virulence factor genes in the microorganisms such as fungi. in the filamentous fungus aspergillus nidulans, the gene sidb plays an essential role in septation, conidiation and vegetative hyphal growth. in the present study, we benefited from the rnai strate...

background vancomycin-resistant enterococci (vre) are the most common nosocomial pathogen worldwide. colonization with vre can lead to serious infection, some of which e.g. vre sepsis can be fatal. because vre are dangerous important pathogens, we aimed to determine the prevalence of vre among patients admitted in infectious, icu and surgery wards in a referral teaching hospital in isfahan, ira...

conclusions according to the role of different genera of fungi in the process of otomycosis, much attention on the macroscopic and microscopic examination of the samples leads to special treatment decisions of a physician. results thirty-three patients (55.36%) were female and the rest were male. fungal elements were observed in 11 cases (19.64%) in the direct examination, alone, and 45 specime...

conclusions: the overall results of the analysed samples showed that the rate of fungal contamination in pure samples was higher than roasted with salt ones (p < 0.005). results of the current survey could be useful for minimizing fungal contamination and can educate people about the dangers of mold in nuts. background: nuts are one of the main consumed snacks worldwide and a significant compon...