نتایج جستجو برای: v notch
تعداد نتایج: 321822 فیلتر نتایج به سال:
Machine parts are exposed to stress accumulation due geometric differences. Determining the locations is crucial design procedures. Studies on concentrations have been conducted in past using a variety of theoretical and experimental methodologies, distinct interpretations offered depending geometry machine part be produced. The ability complete activities with least amount effort shortest time...
Genetic and phenotypic analysis of strawberry notch suggests that its gene product is required during embryogenesis and oogenesis, and for the development of the eye, wing and leg. Several lines of evidence suggest that strawberry notch participates together with Notch in many common pathways. A number of strawberry notch mutant phenotypes are similar to those of Notch mutants and can be rescue...
Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity. Here we provide evidence for Notch regulation at an earlier step - mRNA 3' processing. Processing at the Notch consensus polyadenylation site appears by default to be suppressed in Drosophila embryos. Interference w...
References 1. Artavanis-Tsakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776. 2. Artavanis-Tsakonas S, Matsuno K, Fortini ME: Notch signaling. Science 1995, 268:225-232. 3. Petcherski AG, Kimble J: LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway. Nature 2000, 405:364-368. 4. Lehmann R, Jim...
BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...
High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is necessary to determine which patients may benefit from Notch inhibitors, which agents should be combined with them, and which biomarkers indicate Notch activity in vivo. We explored expression of Notch receptors and liga...
In this paper Cobalt-Chromium-Molybdenum (Co-Cr-Mo) specimens produced by Selective Laser Melting (SLM) for biomedical field were studied. particular, fatigue tests carried out comparing as-built condition with Hot Isostatic Pressing (HIP) and a heat treatment under vacuum condition. The influence on microstructure properties was investigated plain V-notched geometry. Both HIP had effects the i...
AIMS Notch and activin receptor-like kinase 1 (ALK1) have been implicated in arterial specification, angiogenic tip/stalk cell differentiation, and development of arteriovenous malformations (AVMs), and ALK1 can cooperate with Notch to up-regulate expression of Notch target genes in cultured endothelial cells. These findings suggest that Notch and ALK1 might collaboratively program arterial ide...
این پژوهش سعی بر آن داشت تا سه کتاب رایج آموزش زبان انگلیسی در موسسات اصفهان را مورد ارزیابی قرار دهد. به این منظور، ابتدا پیمایشی انجام شد که نشان داد سه کتاب four corners،top notchو interchange بیشتر از دیگرکتابهای موجود در بازار مورد استقبال و استفاده این موسسات قرار گرفته اند. پس از انتخاب کتابها برای ارزیابی، این پژوهش در دو مرحله انجام گرفت. در مرحله اول، برای تعیین ملاک های ارزیابی سه کت...
Background: Mandibular ramus undergoes remodelling with time. The remodeling is also influenced by factors such as ageing, dental status, gender, stress, trauma, force exerted during occlusion, and joint diseases. Studies have reported variations in morphology of coronoid process, condylar sigmoid notch the mandible. Objectives: To assess morphological processes mandible a tertiary care centre ...
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