نتایج جستجو برای: validation studies publication type
تعداد نتایج: 2919432 فیلتر نتایج به سال:
We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might improve the success rate of central nervous systems research and development (CNS R&D) projects. We su...
Plant macrofossils and pollen play complementary roles in paleoecology. Each has its own advantages and shortcomings. Used separately, they provide valuable information about past vegetation. Used together, the two types of data can corroborate or, occasionally, challenge each other, and they can provide more detailed and refined understanding of past vegetation at multiple spatial scales. In t...
Most of the macromolecular structures in the Protein Data Bank (PDB), which are used daily by thousands of educators and scientists alike, are determined by X-ray crystallography. It was examined whether the crystallographic models and data were deposited to the PDB at the same time as the publications that describe them were submitted for peer review. This condition is necessary to ensure pre-...
Background : Meta analysis is a statistical method to combine the findings of a set of large number of published individual studies and re-analyse them. The use of meta-analysis methods in medical research has been increased, noticeably, in resent years. However, one of the major shortcomings in such analysis is that the researcher, could not access all conducted studies in the area of concern...
The importance of validation techniques in X-ray structure determination and their relation to refinement procedures are discussed, with particular reference to atomic resolution structures. The requirements of deposition and publication, and the role of validation tools in this are analysed. The need for a rigorously defined file format is emphasized.
PURPOSE In this article, I consider how research, clinical expertise, client values, a clinician's theoretical perspective, and service delivery considerations affect the decisions that clinicians make to treat children with speech-sound disorders (SSD). METHOD After reviewing the research on phonological treatment, I discuss how a clinician's theoretical perspective influences goal selection...
This is the 54th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, and which reduce, refine or replace the use of laborator...
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