Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which been linked cellular uptake and efflux, apoptosis, vascular injury, oxidative endoplasmic reticulum stress, inflammation. Despite research efforts, pharmaceutical interventions, clinical trials spanning over several decades, consist...

ABSTRACT Chronic kidney disease (CKD) represents an independent risk factor for cardiovascular diseases (CVD). Accordingly, CKD patients show a substantial increased of mortality. Inflammation important link between and CVD. The interaction endothelial cells effector the innate immune system plays central role in development progression inflammation. Vascular injury causes dysfunction, leading ...

Penetrating traumas to the gluteal region can occur via vascular injury, nerve injuries, or damage perineal organs. Vascular injuries are usually life-threatening in penetrating traumas. Therefore, use of angiograms may be necessary for management assess bleeding focus. Herein, case a 24-year-old male who applied emergency department with stab wound injury is presented. Digital subtraction angi...

Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. The present study aimed to detect endogenous APN and its receptor expression and their protective effects against hypertensive vascular injury. APN was ma...

Survivin is a protein member of the inhibitor of apoptosis family that has attracted attention for its dual essential roles in the regulation of cell division and the control of apoptosis. Although extensively characterized as a tumor gene and exploited for new opportunities in cancer diagnostics and therapeutics, fresh experimental evidence has uncovered a critical role of survivin in vascular...

T he health of the vascular endothelium is critical for normal vascular physiologic function, and dysfunction of the endothelium can lead to development of vascular disease, such as atherosclerosis and thrombosis. Endothelial cells (ECs) integrate hemodynamic and biochemical signals to regulate principal vascular functions, including vasoreactivity, permeability, immune cell homing, and thrombo...

Twenty-three cases of arterial injury after 8,208 arterial catheterizations for diagnostic or therapeutic indications at Glasgow Royal Infirmary are reviewed. Clinical presentation included haematoma formation, development of an acutely ischaemic limb or a false aneurysm. Patients with valvular heart disease are identified as a high risk group. Nine cases were managed by simple suture of the pu...

The hepatic circulation is unique in that high volumes of low pressure blood flow are supplied through a dual venous and arterial circulation. This vascular supply is modulated both by the gastrointestinal vascular bed and an intrahepatic microcirculation. This complex vascular system is influenced by pathologic processes within the liver. Alterations in the hepatic circulation reflect hepatic ...

BACKGROUND Peripheral vascular injuries are frequently encountered in lethal and nonlethal trauma. Although significant improvements in treatment have been achieved, such injuries are still important causes of mortality. METHODS In this study, the records of 6769 autopsies performed between 1996 and 2006 at the Council of Forensic Medicine Bursa Group Chairmanship Morgue Department were evalu...

Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that may augment tissue injury in excess of that produced by ischaemia alone. Cellular damage after reperfusion of previously viable ischaemic tissues is defined as ischaemia-reperfusion (I-R) injury. I-R injury ...