We have examined the relationship between insulin-induced receptor downregulation and the induction of a postreceptor defect in the insulin-stimulated glucose transport system in rat adipocytes, and found that downregulation was linked to the expression of the postreceptor defect. When recycling of insulin receptors was inhibited by 20 mM Tris, insulin pretreatment (100 ng/ml) for 4 h at 37 deg...

To clarify the characteristics of the first heart sound in atrial septal defect (ASD) and its pathophysiological basis, 17 patients with ASD associated with incomplete right bundle branch block (IRBBB) and 7 with isolated IRBBB were studied using phonoechocardiography and Doppler echocardiography. Fifteen of the 17 ASD patients also were studied following surgical closure of the defect. Indices...

Gitelman's syndrome, also known as 'hypocalciuric variant' of Bartter's syndrome, is a primary renal tubular disorder characterized by chronic hypokalaemia, hypomagnesaemia, metabolic alkalosis, hypocalciuria with normocalcaemia, hyperreninaemic hyperaldosteronism, and normal renal function [1—3]. The clinical features allowing its differentiation from 'classical' Bartter's syndrome include low...

Quasicrystals and ordinary crystals both possess long-range translational order. But quasicrystals are aperiodic since their symmetry is non-crystallographic. The aim of this project is to study the behavior of shock waves in periodic and aperiodic structures and to compare the results. The expectation is that new types of defects are generated in the aperiodic materials. The materials studied ...

Telomere-led chromosome movements are a conserved feature of meiosis I (MI) prophase. Several roles have been proposed for such chromosome motion, including promoting homolog pairing and removing inappropriate chromosomal interactions. Here, we provide evidence in budding yeast that rapid chromosome movements affect homolog pairing and recombination. We found that csm4Δ strains, which are defec...

Spatiotemporal disorder is studied in traveling-wave convection in ethanol-water mixtures. Spectral measures of disorder, linear correlation functions and mutual information are used to characterize the patterns and are found to give a weak indication of the level of disorder. The calculation of the complex order parameter for experimental patterns is described. It is found that the ordering of...

Defects in DNA replication are associated with genetic instability and cancer development, as illustrated in Bloom syndrome. Features of this syndrome include a slowdown in replication speed, defective fork reactivation and high rates of sister chromatid exchange, with a general predisposition to cancer. Bloom syndrome is caused by mutations in the BLM gene encoding a RecQ helicase. Here we rep...

A low-cost, manufacturable defect gettering and passivation treatment, involving simultaneous anneal of a PECVD SiNx film and a screen-printed Al layer, is found to improve the lifetime in Si ribbon materials from 1-10 μs to over 20 μs. Our results indicate that the optimum anneal temperature for SiNx-induced hydrogenation is 700°C for EFG and increases to 825°C when Al is present on the back o...

Abstract Systems coupling fluids and polymers are of great interest in many branches of sciences. One of the most classical models to describe them is the FENE (Finite Extensible Nonlinear Elastic) dumbbell model. We prove global existence of weak solutions to the FENE dumbbell model of polymeric flows. The main difficulty is the passage to the limit in a nonlinear term that has no obvious comp...