Raloxifene (RAL) and alendronate (ALN) improve the biomechanical properties of bone by different mechanisms. The goal here was to investigate the effects of combination treatment of RAL and ALN on the biomechanical properties of vertebral bone. Six-month-old Sprague-Dawley rats (n = 80) were randomized into five experimental groups (sham, OVX, OVX + RAL, OVX + ALN, and OVX + RAL + ALN; n = 16/g...

Introduction: Vertebral collapse is associated with breakdown of vertebra resulting in decrease in height of vertebral body. Magnetic Resonance Imaging is well known method to evaluate bone and bone marrow diseases, one of the reliable markers to differentiate between benign and malignant compressive fractures and certain characteristics which aids in early differentiation of benign and maligna...

OBJECTIVES Grip strength has been reported to be associated with bone mass locally at the forearm and also at distant skeletal sites, including the spine and hip. Less is known about the association between low grip strength and risk of vertebral fracture. The aim of this study was to examine the association between low grip strength, bone mineral density at the hip and spine, and vertebral fra...

STUDY DESIGN Retrospective study. PURPOSE This study was conducted to compare vertebral body height restoration rate in rheumatoid arthritis (RA) patients who had undergone percutaneous balloon kyphoplasty (KP) with that of control group who had matched age, sex, body mass index, and bone mineral density. OVERVIEW OF LITERATURE There is no report on result of KP in RA patients. METHODS Po...

conclusion there are significant differences between vo by different microorganisms that help physician to start empirical medical treatment while waiting to definite diagnosis by blood culture, culture from paravertebral abscess, serology and bone biopsy. spinal osteomyelitis is an uncommon cause of back pain but it has potential to compromise nervous system and even death may occur if it is n...

We report the case of a 25-year-old Caucasian woman with symptomatic monostotic fibrous dysplasia of the fourth lumbar vertebral body. The patient suffered from a five-week history of progressive low back pain, radiating continuously to the left leg. Her medical history and physical and neurological examination did not demonstrate any significant abnormalities. Radiographs, computed tomography ...

To prevent osteoporotic fracture occurrence, a variety of treatment regimens with different mechanisms of action is available. The antiresorptive bisphosphonate drugs are currently the most commonly prescribed agents in the management of patients with osteoporosis. The recombinant amino-terminal fragment of human parathyroid hormone (Teriparatide) is a bone anabolic agent which reduces fracture...

Risedronate is a third generation bisphosphonate used in the prevention of osteoporotic fractures and the treatment of Paget’s disease. In patients with osteoporosis, risedronate reduces bone turnover, improves bone density and reduces the risk of both vertebral and non-vertebral fractures. Efficacy has been established in the treatment of postmenopausal osteoporosis, osteoporosis in men, and i...

STUDY DESIGN Ex vivo biomechanical study using osteoporotic cadaveric vertebral bodies. OBJECTIVE To determine if fracture reduction could be achieved by the inflatable bone tamp (tamp) in vertebral bodies under simulated physiologic loads. SUMMARY OF BACKGROUND DATA Previous ex vivo biomechanical studies showed that kyphoplasty restored vertebral body height with vertebral body endplates u...

As the world's population ages, the incidence of osteoporosis defined by decreased bone mass and alteration of microarchitecture has inevitably increased. This results in osteoporosis-associated fracture and leads to debilitating health outcomes and a considerable economic burden on the health care system. In this issue of the Journal of the Chinese Medical Association, Lin and colleagues have ...