BACKGROUND AND PURPOSE Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity. METHODS Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct s...

Figure 1. Frequencies of comorbid epilepsy in children with autism from Simons Simplex Collection as function of full-scale IQ (Differential Ability Scales—II, Mullen Scales of Early Learning, Wechsler Abbreviated Scale of Intelligence, or Wechsler Intelligence Scale for Children—IV). pilepsy occurs in 5% to 40% of individuals with autism, whereas the prevalence in the general population is abo...

Visual evoked potential (VEP) is a technique used to assess the brain's electrical response to visual stimuli. The aims of this study were to examine neural transmission within the visual pathway through VEP testing in preschool children with autism spectrum disorder (ASD) and compare it to age-matched controls, as well as search for a correlation between the VEP parameters and the symptoms of ...

Purpose: To explore the presence of subtypes of intellectual functioning in children with mild intellectual disability (ID) and to externally validate the subtypes on measures of academic, adaptive and psychosocial functioning. Method: Participants were 167 children age 6-16 years with a mild ID. All children completed the WISC-III, WIAT, VABS, and PIC-R. Results: Based on a two-stage cluster a...

The number of diagnosed cases of Autism Spectrum Disorders (ASD) has increased dramatically over the last four decades; however, there is still considerable debate regarding the underlying pathophysiology of ASD. This lack of biological knowledge restricts diagnoses to be made based on behavioral observations and psychometric tools. However, physiological measurements should support these behav...

Adaptive behavior has become an increasingly important component of the assessment of children referred for learning and behavioral problems in educational settings. Yet the construct of adaptive behavior remains ill defined, and fundamental questions about the nature of adaptive behavior remain unanswered. As a result, measures of adaptive behavior are often problematic. Among the most importa...

This paper presents the development of a mixed-variable optimization framework for the aeroelastic analysis and design of active twist rotors. Proper tailoring of the blade properties can lead to the maximization of the active twist and the control authority for vibration reduction under operating conditions. Thus, using mathematical optimization, the crosssectional layout is designed using con...

A general formulation for the reduction of the three-dimensional problem of electrothermoelasticity in slender solids to an arbitrarily defined reference line is presented. The dimensional reduction is based on a variationalasymptotic formulation, using the slenderness ratio as small parameter. In the proposed scheme, the coupled linear electroelastic equations are solved at the cross-sectional...

OBJECTIVE In fragile X syndrome (FXS), it is hypothesized that absence of the fragile X mental retardation protein (FMRP) disrupts regulation of group 1 metabotropic glutamate receptor (mGluR and mGluR5)-dependent translation in dendrites. Lithium reduces mGluR-activated translation and reverses phenotypes in the dfxr mutant fly and fmr1 knockout mouse. This pilot add-on trial was conducted to ...

BACKGROUND Prenatal exposure to alcohol often results in disruption to discrete cognitive and behavioral domains, including executive function (EF) and adaptive functioning. In the current study, the relation between these 2 domains was examined in children with histories of heavy prenatal alcohol exposure, nonexposed children with a diagnosis of attention-deficit/hyperactivity disorder (ADHD),...