نتایج جستجو برای: viral inactivation of plasma products
تعداد نتایج: 21227279 فیلتر نتایج به سال:
The high affinity of baricitinib for the numb-associated kinase (NAK) family, its anti-inflammatory properties, with its advantageous pharmacokinetic properties, appear to make it a special case among the approved drugs. In addition, the potential for combination therapy with baracitinib is high, because of its low plasma protein binding and minimal interaction with CYP enzymes and drug transp...
Inactivated polio vaccines, which have been used in many countries for more than 50 years, are produced by treating live poliovirus (PV) with formaldehyde. However, the molecular mechanisms underlying virus inactivation are not well understood. Infection by PV is initiated by virus binding to specific cell receptors, which results in viral particles undergoing sequential conformational changes ...
Background to plasma-derived medicines Although the first plasma-derived medicines were anti-toxins, raised in horses against pathogens (diphtheria, tetanus)1, the inception of plasma protein therapy occurred when Edwin Cohn developed his fractional ethanol precipitation scheme to isolate a stable albumin solution for the treatment of battle fi eld injury and blood loss2. The Cohn scheme yielde...
Since the start of COVID-19 outbreak, more than four million people have died this disease. Given its ability to provide a precise response, mass spectrometry-based proteomics could represent useful tool study pathology. To end, an untargeted nLC-ESI-MS/MS-based method characterise SARS-CoV-2 proteins, including possible variants, and investigate human saliva plasma proteome in single analysis ...
Background : Molecular diagnostic methods are among major tools in management of hepatitis C virus (HCV) in infected patients. Many studies have shown that viral load is associated with stage of infection and response to treatment. Therefore, the evaluation and quantification of viral load is very important. The goal of this study is implementation of inexpensive, yet accurate method for quanti...
BACKGROUND Thrombolytic therapy induces a procoagulant state characterized by elevated plasma levels of fibrinopeptide A (FPA), but the responsible mechanism is uncertain. METHODS AND RESULTS Washed plasma clots were incubated in citrated plasma in the presence or absence of tissue plasminogen activator (t-PA), and FPA generation was monitored as an index of unopposed thrombin activity. FPA l...
BACKGROUND Zika virus (ZIKV) is an emerging mosquito-borne Flavivirus of major public health concern. The potential for ZIKV transmission by blood transfusion has been demonstrated; however, inactivation or removal of ZIKV during the manufacture of plasma-derived medicinal products has not been specifically investigated. STUDY DESIGN AND METHODS Inactivation of ZIKV by pasteurization and solv...
Background: Plasma medicine is an innovative and emerging field used in a broad range of medical conditions. Objective: The present study focused on consumption, documentation pattern and traceability of plasma-derived medicines in a teaching and referral hospital. Method: A two-step study was conducted from October to December 2015. During the first phase, the patient records receiving plasm...
Background: Plasma medicine is an innovative and emerging field used in a broad range of medical conditions. Objective: The present study focused on consumption, documentation pattern and traceability of plasma-derived medicines in a teaching and referral hospital. Method: A two-step study was conducted from October to December 2015. During the first phase, the patient records receiving plasm...
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