Ovarian epithelial cancer is a leading cause of death among gynaecological malignancies due mainly to advanced stage at presentation. Aim of the work: The purpose of this study was to investigate the expression and prognostic significance of CD44v6, Bcl-2 and P53 in ovarian tumors of low malignant potential (LMP) and primary epithelial ovarian carcinomas Experimental Design: We analyzed the imm...

Purpose: The purpose of this research was to examine the DNA methylation profiles of primary sporadic ovarian cancers and ovarian tissues from high-risk women. Experimental Design: We analyzed the DNA methylation status of nine cancer-related genes in 49 primary ovarian tumors, 39 nonmalignant ovarian tissues obtained from 16 women with no known risk and from 23 high-risk women with a strong fa...

Pseudomyxoma peritonei is only rarely seen in conjunction with primary ovarian tumors. It has been suggested that only ruptured mucinous tumors arising in ovarian mature cystic teratomas can result in this clinical picture. We describe a case of a late invasive recurrence of a mucinous intestinal-type borderline ovarian tumor arising from a mature teratoma after complete surgical debulking. Bor...

BACKGROUND Human papillomavirus (HPV) is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. OBJECTIVES This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian tumor tissues. PATIENTS AND METHODS This was a retrospective study, which included 61 Archived human ovarian tumor tissues embedded in paraffin blo...

OBJECTIVE To detect the expression and clinical significances of Lewis y antigen and integrin αv, β3 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin αv, β3. METHODS Immunohistochemical staining was performed in 95 cases of epithelial ovarian cancer, 37 cases of borderline tumors, 20 cases of benign tumors, and 20 cases of normal ova...

PURPOSE To elucidate the molecular mechanisms contributing to the unique clinicopathologic characteristics of mucinous ovarian carcinoma, global gene expression profiling of mucinous ovarian tumors was carried out. EXPERIMENTAL DESIGN Gene expression profiling was completed for 25 microdissected mucinous tumors [6 cystadenomas, 10 low malignant potential (LMP) tumors, and 9 adenocarcinomas] u...

BACKGROUND We showed there are specific ALDH1 autoantibodies in ovarian autoimmune disease and ovarian cancer, suggesting a role for ALDH1 in ovarian pathology. However, there is little information on the ovarian expression of ALDH1. Therefore, we compared ALDH1 expression in normal ovary and benign and malignant ovarian tumors to determine if ALDH1 expression is altered in ovarian cancer. Sinc...

PURPOSE Jab1 (Jun activation domain-binding protein 1) has been described as a coactivtor of AP1 transcription factor, and is a subunit of a large protein complex (called the COP9 signalosome). Recent study (K. Tomoda et al., Nature (Lond.), 398: 160-165, 1999) found that Jab1 protein can cause breakdown of p27(kip1) protein in mammalian cells. To investigate whether Jab1 expression is correlat...

Epithelial carcinoma of the ovary is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women. Currently blood test of advanced epithelial tumors are reflected in a high level of CA 125 antigen. However, it is not a good marker for early stage tumors, and may yield false positives. Clearly, there is a need for better understanding of the molec...

Most human ovarian tumors are classified into one of several categories based on presumed histogenesis and direction of differentiation. Separate categories are reserved for neoplasms composed of cells of several origins and for nonneoplastic disorders that simulate neoplasms. Using the World Health Organization Histologic Classification of Ovarian Tumors, histologic features for common and rar...